Biomarker evaluation of self-reported condom use among women in HIV-discordant couples.
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Date
2013Author
Mose, F
Newman, L
Njunguna, R
Tamooh, H
John-Stewart, G
Farquhar, C
Kiarie, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Self-reported condom use is a commonly collected statistic, yet its use in research studies may be inaccurate. We evaluated this statistic among women in HIV-discordant couples enrolled in a clinical trial in Nairobi, Kenya. Vaginal swabs were acquired from 125 women and tested for prostate-specific antigen (PSA), a biomarker for semen exposure, using an enzyme-linked immunosorbent assay. Ten (10%) of 98 women who reported 100% use of condoms in the previous month tested PSA positive. In a bivariate logistic regression analysis, among women who reported 100% condom use in the previous month, those with ≤8 years of school had significantly higher odds of testing PSA-positive (odds ratio [OR] = 8.39, 95% confidence interval [CI] 1.02-69.13) than women with more schooling. Our estimate may be conservative, as the ability to detect PSA may be limited to 24-48 hours after exposure. Less educated women may be a target group for counselling regarding reporting sexual behaviour in clinical trials.
URI
http://www.ncbi.nlm.nih.gov/pubmed/23970768http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57402
Citation
Int J STD AIDS. 2013 Jul;24(7):537-40. doi: 10.1177/0956462412473892. Epub 2013 Jul 19.Publisher
University of Nairobi School of Medicine
Collections
- Faculty of Health Sciences (FHS) [10378]