dc.contributor.author | Black, CL | |
dc.contributor.author | Mwinzi, PN | |
dc.contributor.author | Muok, EM | |
dc.contributor.author | Carter, JM | |
dc.contributor.author | Karanja, DM | |
dc.contributor.author | Secor, WE | |
dc.contributor.author | Colley, DG | |
dc.date.accessioned | 2013-10-15T09:34:04Z | |
dc.date.available | 2013-10-15T09:34:04Z | |
dc.date.issued | 2010-08 | |
dc.identifier.citation | Black CL, Muok EM, Mwinzi PN, Carter JM, Karanja DM, Secor WE, Colley DG. Increases in levels of schistosome- specific immunoglobulin E and CD23 (+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with schistosoma mansoni | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/20560767 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57639 | |
dc.description.abstract | BACKGROUND:
Age prevalence curves for areas in which schistosomiasis is endemic suggest that humans develop partial immunity to reinfection beginning in early adolescence. We conducted a 2-year longitudinal study to determine whether children infected with Schistosoma mansoni develop protection-related immune responses after treatment with praziquantel and whether the development of these immune responses is accelerated by frequent treatment after reinfection.
METHODS:
Children (8-10 years old) were tested for S. mansoni every 4 months and treated with praziquantel when positive (arm A; n=68) or were tested and treated at the end of the 2-year follow-up period (arm B; n=49).
RESULTS:
Children in arm A who remained free of infection during follow-up had significantly higher baseline levels of schistosome-specific immunoglobulin E (IgE) than did children with > or =2 repeat diagnoses of S. mansoni infection. Children with > or =2 repeat diagnoses of S. mansoni infection had significantly increased levels of anti-schistosome IgE and CD23(+) B cells after receiving > or =3 praziquantel treatments over the course of follow-up. No increase in either parameter was seen in children who received only the baseline praziquantel treatment.
CONCLUSIONS:
B cell activation and anti-schistosome IgE are associated with resistance to S. mansoni in children, and these immunological parameters can be increased by multiple rounds of infections and praziquantel-induced cures | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Increases in levels of schistosome-specific immunoglobulin E and CD23 (+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with schistosoma mansoni. | en |
dc.type | Article | en |
local.publisher | College of Health Science | en |