T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.
Date
2007-10Author
Watanabe, K
Mwinzi, PN
Black, CL
Muok, EM
Karanja, DM
Secor, WE
Colley, DG
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Schistosomiasis mansoni is usually a chronic infection that leads to long-term, systemic exposure to schistosome antigens. Experimental Schistosoma mansoni infection is associated with immunoregulatory mechanisms, including T regulatory cells (Treg) that may help control morbidity and dampen resistance to re-infection. We now show that some schistosomiasis mansoni patients have high proportions of CD3(+)/CD4(+)/CD25(high) Treg. On effective treatment with praziquantel, these high Treg percentages decrease, and fewer of the remaining Treg express CD45RO. The proportion of Treg in S. mansoni-infected patients is inversely related to their percentage of activated, putative effector T cells (CD3(+)/CD4(+)/CD25(medium)/HLA-DR(+) cells). We conclude some, but not all, schistosomiasis mansoni patients develop high percentages of circulating Treg, and effective treatment both decreases the levels of these cells and changes their phenotypes, possibly because of the removal of constant exposure to antigens from intravascular, egg-producing adult worms.
URI
http://www.ncbi.nlm.nih.gov/pubmed/17978070http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57647
Citation
Am J Trop Med Hyg. 2007 Oct;77(4):676-82.Publisher
University of Nairobi College of Health Science
Collections
- Faculty of Health Sciences (FHS) [10377]