dc.contributor.author | Mwinzi, PN | |
dc.contributor.author | Karanja, DM | |
dc.contributor.author | Kareko, I | |
dc.contributor.author | Magak, PW | |
dc.contributor.author | Orago, AS | |
dc.contributor.author | Colley, DG | |
dc.contributor.author | Secor, WE | |
dc.date.accessioned | 2013-10-16T06:06:16Z | |
dc.date.available | 2013-10-16T06:06:16Z | |
dc.date.issued | 2004 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57654 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/15642972 | |
dc.description | Journal Article | en |
dc.description.abstract | Abstract
To investigate whether infection with human immunodeficiency virus 1 (HIV-1) affects fibrosis development in patients infected with Schistosoma mansoni, we evaluated schistosomiasis-induced pathology in the livers of Kenyan patients co-infected with HIV-1. Compared with persons with schistosomiasis alone (n = 58), there were no significant differences in distribution of ultrasound-detectable pathology in persons with HIV-1 co-infection (n = 23). Similarly, serum aspartate aminotransferase levels were not significantly different in HIV-1+ individuals. Hepatic fibrosis was associated with significantly decreased CD4+ T cell counts, even in the absence of HIV-1 infection. These data suggest that HIV-1 co-infection does not significantly alter the proportion of patients experiencing schistosomiasis-induced fibrosis, but pathology associated with S. mansoni infections leads to CD4+ T cell reductions and thereby may exacerbate the effects of HIV-1 in co-infected individuals | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1. , ,, , , . | en |
dc.type | Article | en |
local.publisher | College of Health Science | en |