Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

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Date
2012
Author
Levine, RL
Abdel-Wahab, O
Brennan, CW
Godley, LA
Melnick, A
Mason, CE
Gonen, M
Bhatt, PK
Socci, N
Hassimi, M
Heguy, A
Viale, A
Li, J
Mollica, L
Hamilou, Z
Provost, S
Vasanthakumar, A
Busque, L
Patel, JP
Figueroa, ME
Type
Article
Language
en
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Abstract
Abstract Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematological malignancies and were associated with alterations in DNA methylation
URI
http://www.ncbi.nlm.nih.gov/pubmed/23001125
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57957
Publisher
College of Biological and Physical Sciences ,Department of physics
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