HLA antigens in East African Black patients with Burkitt's lymphoma or nasopharyngeal carcinoma and in controls: a pilot study
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Date
1982-10Author
Hall, PJ
Levin, AG
Entwistle, CC
Knight, SC
Wasunna, A
Kung'u, A
Brubaker, G
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A pilot study is reported of HLA-A, B, and C antigens in 141 East African Blacks comprising patients with Burkitt's lymphoma or nasopharyngeal carcinoma, either with active disease or in long-term remission, together with comparable controls. This study forms part of a wider program investigating host factors in these diseases. A protocol was selected for optimal testing of cells processed and cryopreserved between 1972 and 1976, largely under field conditions, which employed a two-color fluorochromasia typing procedure. Antigen distribution and computed haplotype frequencies in the total unrelated population are given. New findings include an approximately equal frequency of Aw23 and Aw24, a high (18%) incidence of Bw21, and the gametic associations of Aw36 with Bw44, and Aw30 with Bw45. Of the major group of B15-related antigens reported earlier. SV is the most common, and there are strong linkages of SV with Cw2 and Bu with Cw3. The possible presence of further variants at the A- and B-loci is reported. The proportion of B-locus antigen "blanks" in this study is 5.9%. Relationships have been sought between the HLA antigens and diseases studied: the antigen A29, possibly in linkage with Bw42, shows a correlation with disease susceptibility, and associations are suggested between Bw44 (in possible combination with Aw36) and resistance to both BL and NPC, and between Bw45 and long-term remission in NPC.
URI
http://www.ncbi.nlm.nih.gov/pubmed/7141899http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/58214
Citation
Hum Immunol. 1982 Oct;5(2):91-105Publisher
University of Nairobi, School of Medicine
Collections
- Faculty of Health Sciences (FHS) [10377]