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    Safety And Contraceptive Studies Of Unipron

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    Date
    2013-06
    Author
    Obiero, Jael A
    Mulei, Isaac
    Farah, Idle O
    Linge, Kavoo
    Jaoko, Walter
    Mwethera, Peter G
    Type
    Presentation
    Language
    en
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    Abstract
    Introduction: Two of the major challenges in reproductive health are the failure to reduce family size and acquisition of Sexually Transmitted Infections (STIs) including Human Immunodeficiency Virus (HIV). Limited availability of woman-initiated non-hormonal contraceptive programmes is a hindrance to successful contraceptive programmes in resource-constrained countries. In this study we assessed the safety of UniPron as a vaginal product and its effectiveness as a contraceptive in female olive baboons (Papio anubis). Objectives: (i) To evaluate the effect of UniPron on baboon vaginal pH and vaginal flora (ii) To evaluate the effect of UniPron on blood chemistry profile of baboons (iii) To evaluate the effect of UniPron on baboon vaginal and cervical epithelia (iv) To determine the effectiveness of UniPron as contraceptive in a baboon Outcome measures: Changes in baboon vaginal pH, vaginal flora, clinical chemistry profile and conception Results: Baseline vaginal pH was 5.8±0.8. There was no significant difference in the vaginal pH of Smugel treated animals compared to baseline (p>0.05). Similarly, analysis of blood chemistry parameters revealed no significant differences. The most frequently isolated microorganisms both at baseline and during treatment included Corynebacterium glucuronolyticum, C. renale group, Lactococcus raffinolactis, Leuconostoc lactis, Lactobacillus acidophilus, L. fermentum, L. salivarius, Staphylococcus aureus, S. xyloxus, S. hyicus, Aerococus viridians, Escherichia coli and Candida albicans. No detectable histological changes were observed in the vaginal or cervical sections examined. During treatment intravaginally with UniPron no conception occurred in the Uni Pron treated animals, except when the treatment was stopped. Conclusions and Recommendations: Unipron is safe as a vaginal product in baboons and is effective as a reversible contraceptive. Further studies should be conducted to assess the safety of UniPron as a vaginal product in women.
    URI
    http://hdl.handle.net/11295/61120
    Citation
    Jael A. Obiero, Isaac Mulei2,Idle O. Farah, Kavoo Linge, Walter Jaoko, Peter G. Mwethera;Safety And Contraceptive Studies Of Unipron,presented at the 2nd International Scientific Conference, Chs And Knh, 19th - 21st June 2013.
    Publisher
    University of Nairobi
     
    College of Health Sciences
     
    Subject
    UniPron, Safety, Contracetive, Papio anubis
    Description
    Safety And Contraceptive Studies Of Unipron,presented at the 2nd International Scientific Conference, CHS And KNH, 19th - 21st June 2013.
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    • Faculty of Health Sciences (FHS) [852]

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