dc.contributor.author | Kahle, E | |
dc.contributor.author | Campbell, M | |
dc.contributor.author | Lingappa, J | |
dc.contributor.author | Donnell, D | |
dc.contributor.author | Celum, C | |
dc.contributor.author | Ondondo, R | |
dc.contributor.author | Mujugira, A | |
dc.contributor.author | Fife, K | |
dc.contributor.author | Mugo, N | |
dc.contributor.author | Kapiga, S | |
dc.contributor.author | Mullins, JI | |
dc.contributor.author | Baeten, JM | |
dc.contributor.author | Partners in Prevention HSVHIV Transmission Study Team | |
dc.date.accessioned | 2014-03-03T13:23:29Z | |
dc.date.available | 2014-03-03T13:23:29Z | |
dc.date.issued | 2014-01 | |
dc.identifier.citation | AIDS. 2014 Jan 14;28(2):235-43. doi: 10.1097/QAD.0000000000000024. | en_US |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/24413311 | |
dc.identifier.uri | http://hdl.handle.net/11295/65054 | |
dc.description.abstract | BACKGROUND:
HIV-1 subtype C has emerged as the most prevalent strain of HIV-1 worldwide, leading to speculation that subtype C may be more transmissible than other subtypes. We compared the risk of HIV-1 transmission for subtype C versus non-C subtypes (A, D, G and recombinant forms) among heterosexual African HIV-1 serodiscordant couples.
METHODS:
We conducted a nested case-control analysis using data from two prospective cohort studies of heterosexual HIV-1 serodiscordant couples from six countries in eastern and southern Africa. Cases (N = 121) included incident HIV-1 transmissions that were established as linked within the serodiscordant partnership by viral sequencing; controls (N = 501) were nontransmitting HIV-1-infected partners. Subtype was determined for partial env and gag genes. Multiple logistic regression controlled for age and gender of the HIV-1-nfected partner and self-reported unprotected sex. Plasma and genital HIV-1 RNA concentrations were compared between subtype C and non-C subtypes using generalized estimating equations.
RESULTS:
HIV-1 subtype C was not associated with increased risk of HIV-1 transmission compared with non-C subtypes: env adjusted odds ratio (adjOR) 1.14 [95% confidence interval (CI) 0.74-1.75, P = 0.6] and gag adjOR 0.98 (95% CI 0.63-1.52, P = 0.9). Plasma and genital HIV-1 RNA levels did not differ significantly for subtype C versus non-C.
CONCLUSION:
In a geographically diverse population of heterosexual African HIV-1 serodiscordant couples, subtype C was not associated with greater risk of HIV-1 transmission compared with non-C subtypes, arguing against the hypothesis that subtype C is more transmissible compared with other common subtypes. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | HIV-1 subtype C is not associated with higher risk of heterosexual HIV-1 transmission: a multinational study among HIV-1 serodiscordant couples. | en_US |
dc.type | Article | en_US |