A Comparative Study of Embelia Schiperi and Embelia Keniensis on Blood Glucose and Triglycerides in Normal and Epinephrine- Induced Hyperglycemic Mice
Date
1999Author
Albert, Randrianjafy
Tachibana, Yoko
Nishiyama, Yumi
Mathenge, Simon G
Kato, Atsushi
Miura, Toshihiro
Ohnishi, Yasuhiro
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Intraperitoneal administration of the methanol extract of Embelia schiperi (ES) to normal mice caused a significant decrease in blood glucose (p < 0.01) and a significant increase in triglycerides 4 hours after administration at 100 mg/kg (p < 0.01). The toluene fraction of Embelia keniensis methanol extract (TS) showed hypoglycemic and lipid lowering activity 7 hours after intraperitoneal administration at 100 mg/kg. In addition, TS (100 mg/kg) administration significantly decreased blood glucose in epinephrine-induced hyperglycemic mice (p < 0.01). Moreover, ES tended to increase while TS tended to decrease the blood triglycerides in epinephrine-induced hyperglycemic mice. On the other hand, no changes in blood cholesterol were observed after the administration of ES or TS in normal and epinephrine-induced hyperglycemic mice. We found that two species from Embelia, ES and TS, have different activities on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice.
URI
http://www.worldscientific.com/doi/abs/10.1142/S0192415X99000410http://hdl.handle.net/11295/65726
Citation
Atsushi Kato et al, Am. J. Chin. Med. 27, 365 (1999)Publisher
University of Nairobi