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dc.contributor.authorChasela, CS
dc.contributor.authorKourtis, AP
dc.contributor.authorWall, P
dc.contributor.authorDrobeniuc, J
dc.contributor.authorKing, CC
dc.contributor.authorThai, H
dc.contributor.authorTeshale, EH
dc.contributor.authorHosseinipour, M
dc.contributor.authorEllington, S
dc.contributor.authorCodd, MB
dc.contributor.authorJamieson, DJ
dc.contributor.authorKnight, R
dc.contributor.authorFitzpatrick, P
dc.contributor.authorKamili, S
dc.contributor.authorHoffman, I
dc.contributor.authorKayira, D
dc.contributor.authorMumba, N
dc.contributor.authorKamwendo, DD
dc.contributor.authorMartinson, F
dc.contributor.authorPowderly, W
dc.contributor.authorTeo, CG
dc.contributor.authorvan der Horst, C
dc.contributor.authorBAN Study Team.
dc.contributor.authorMeme, J
dc.date.accessioned2014-04-29T15:15:54Z
dc.date.available2014-04-29T15:15:54Z
dc.date.issued2014-03
dc.identifier.citationJ Hepatol. 2014 Mar;60(3):508-14. doi: 10.1016/j.jhep.2013.10.029. Epub 2013 Nov 6.en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/24211737
dc.identifier.urihttp://hdl.handle.net/11295/66157
dc.description.abstractBACKGROUND & AIMS: The extent of HBV infection to infants of HBV/HIV-coinfected pregnant women in sub-Saharan Africa is unknown. The aim of this study was to assess prevalence of HBV infection among antiretroviral-naïve, HIV-infected pregnant women in Malawi and examine HBV transmission to their infants. METHODS: Plasma from 2048 HIV-infected, Malawian women and their infants were tested for markers of HBV infection. Study participants were provided standard-of-care health services, which included administration of pentavalent vaccine to infants at 6, 10, and 14 weeks of age. RESULTS: One-hundred and three women (5%) were HBsAg-positive; 70 of these HBsAg-positive women were also HBV-DNA-positive. Sixteen women (0.8%) were HBV-DNA-positive but HBsAg-negative. Five of 51 infants (9.8%) born to HBsAg-positive and/or HBV-DNA-positive women were HBV-DNA-positive by 48 weeks of age.HBV DNA concentrations of two infants of mothers who received extended lamivudine-containing anti-HIV prophylaxis were <4 log10 IU/ml compared to ⩾ 8 log10 IU/ml in three infants of mothers who did not. CONCLUSIONS: HBV DNA was detected in nearly 10% of infants born to HBV/HIV-coinfected women. Antenatal testing for HIV and HBV, if instituted, can facilitate implementation of prophylactic measures against infant infection by both viruses.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.subjectAntiviral therapyen_US
dc.subjectHIVen_US
dc.subjectHepatitisen_US
dc.subjectMother-to-child transmissionen_US
dc.subjectSub-Saharan Africaen_US
dc.titleHepatitis B virus infection among HIV-infected pregnant women in Malawi and transmission to infants.en_US
dc.typeArticleen_US


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