Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: the BAN study.
dc.contributor.author | Chasela, CS | |
dc.contributor.author | Wall, P | |
dc.contributor.author | Drobeniuc, J | |
dc.contributor.author | King, CC | |
dc.contributor.author | Teshale, E | |
dc.contributor.author | Hosseinipour, MC | |
dc.contributor.author | Ellington, SR | |
dc.contributor.author | Codd, M | |
dc.contributor.author | Jamieson, DJ | |
dc.contributor.author | Knight, RJ | |
dc.contributor.author | Fitzpatrick, P | |
dc.contributor.author | Kourtis, AP | |
dc.contributor.author | Hoffman, IF | |
dc.contributor.author | Kayira, D | |
dc.contributor.author | Mumba, N | |
dc.contributor.author | Kamwendo, DD | |
dc.contributor.author | Martinson, F | |
dc.contributor.author | Powderly, W | |
dc.contributor.author | van der Horst, C | |
dc.contributor.author | BAN Study Team. | |
dc.contributor.author | Meme, J | |
dc.date.accessioned | 2014-04-29T15:24:36Z | |
dc.date.available | 2014-04-29T15:24:36Z | |
dc.date.issued | 2012-08 | |
dc.identifier.citation | J Clin Virol. 2012 Aug;54(4):318-20. doi: 10.1016/j.jcv.2012.05.003. Epub 2012 Jun 2. | en_US |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22658797 | |
dc.identifier.uri | http://hdl.handle.net/11295/66158 | |
dc.description.abstract | BACKGROUND: In Sub-Saharan Africa, prevalence estimates of hepatitis C virus (HCV) vary widely. OBJECTIVES: To assess the prevalence of HCV infection among HIV-infected, pregnant women screened for a large clinical trial in Lilongwe, Malawi. STUDY DESIGN: Plasma from 2041 HIV-infected, pregnant women was screened for anti-HCV IgG using a chemiluminiscent immunometric assay (CIA). Specimens with a signal-cut-off ratio≥1.00 were considered reactive and those with S/Co ratio<1.00 non-reactive. All CIA-reactive specimens were tested by a recombinant immunoblot assay (RIBA) for anti-HCV and by PCR for HCV RNA. RESULTS: Of 2041 specimens, 110 (5.3%, 95% CI: 4.5-6.5%) were CIA reactive. Of the 109 CIA reactive specimens available for RIBA testing, 2 (1.8%) were positive, 28 (25.7%) were indeterminate, and 79 (72.5%) were negative. All CIA-reactive specimens were HCV RNA negative (n=110). The estimated HCV prevalence based on the screening assay alone was 5.3%; based on supplemental RIBA testing, the status of HCV infection remained indeterminate in 1.4% (28/2040, 95% CI: 0.1-2.0) and the prevalence of confirmed HCV infections was 0.1% (2/2040, 95% CI: 0-0.4%). CONCLUSIONS: HCV seroprevalence among HIV-infected, pregnant women in Malawi confirmed by supplemental RIBA HCV 3.0 is low (0.1%); CIA showed a high false-reactivity rate in this population. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: the BAN study. | en_US |
dc.type | Article | en_US |
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