dc.contributor.author | Kopp, Nadja | |
dc.contributor.author | Diaz, Diana | |
dc.contributor.author | Amacker, Mario | |
dc.contributor.author | Odongo, David O | |
dc.contributor.author | Beier, Konstantin | |
dc.contributor.author | Nitsch, Cordula | |
dc.contributor.author | Bishop, Richard P | |
dc.contributor.author | Daubenberger, Claudia | |
dc.date.accessioned | 2014-07-23T08:52:37Z | |
dc.date.available | 2014-07-23T08:52:37Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Vaccine Volume 28, Issue 1, 10 December 2009, Pages 261–269 | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0264410X09014327 | |
dc.identifier.uri | http://hdl.handle.net/11295/73265 | |
dc.description.abstract | The BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with a range of BM86 homologues expressed in other important tick species. Here we have used a BD86 derived synthetic peptide, BD86-3, to raise a series of mouse monoclonal antibodies. One of these mAbs, named 12.1, recognized BM86 homologues in immuno-histochemical analyses in four out of five tick species including R. (B.) microplus, Rhipicephalus (Boophilus) decoloratus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus. Our results indicate that broadly cross-reactive tick gut binding antibodies can be induced after immunization with a synthetic peptide derived from the protein BD86. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.subject | Tick subunit vaccine development; Synthetic peptide; Immuno-histochemistry; Cross-reactivity | en_US |
dc.title | Identification Of A Synthetic Peptide Inducing Cross-reactive Antibodies Binding To Rhipicephalus (boophilus) Decoloratus, Rhipicephalus (boophilus) Microplus, Hyalomma Anatolicum Anatolicum And Rhipicephalus Appendiculatus Bm86 Homologues | en_US |
dc.type | Article | en_US |
dc.type.material | en | en_US |