dc.contributor.author | Lajoie, J | |
dc.contributor.author | Juno, J | |
dc.contributor.author | Burgener, A | |
dc.contributor.author | Rahman, S | |
dc.contributor.author | Mogk, K | |
dc.contributor.author | Wachihi, C | |
dc.contributor.author | Mwanjewe, J | |
dc.contributor.author | Plummer, F A | |
dc.contributor.author | Kimani, J | |
dc.contributor.author | Ball, T B | |
dc.contributor.author | Fowke, K R | |
dc.date.accessioned | 2014-08-14T11:34:11Z | |
dc.date.available | 2014-08-14T11:34:11Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Lajoie, J., et al. "A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers." Mucosal immunology 5.3 (2012): 277-287. | en_US |
dc.identifier.uri | http://www.nature.com/mi/journal/v5/n3/abs/mi20127a.html | |
dc.identifier.uri | http://hdl.handle.net/11295/73758 | |
dc.description.abstract | The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed seronegative (HESN) individuals serves as a model to identify the correlates of protection and to aid in microbicide development. A total of 22 cytokines/chemokines were analyzed at the systemic and mucosal compartments in 57 HESN, 51 HIV-1-negative, and 67 HIV-1-infected commercial sex workers from Nairobi, Kenya. HESN individuals had significantly lower expression of monokine induced by interferon-γ (MIG), interferon-γ-induced protein 10 (IP-10), and interleukin-1α (IL-1α) in their genital mucosa compared with controls. HESN cytokine expression also distinctly correlates with mucosal antiproteases, suggesting that HESN individuals have a unique pattern of mucosal chemokine/cytokine expression, which may result in reduced trafficking at the mucosa. These data support the immune quiescence model of protection, whereby lower T-cell activation/recruitment at the mucosal compartment reduces HIV-1 target cell numbers and is an important component of natural protection from HIV-1. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi, | en_US |
dc.title | A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers | en_US |
dc.type.material | en | en_US |