Browsing Journal Articles by Author "012d7987-dd61-4622-bbdb-40a878669e72"
Now showing items 1-7 of 7
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Adapting a stigma scale for assessment of Tuberculosis-related stigma among English/Swahili-speaking patients in an African setting.
Marangu, D; Mwaniki, H; Nduku ., S; Maleche-Obimbo, E; Jaoko, W; Babigumira, J; John-Stewart, G; Rao, D (University of Nairobi, 2017)OBJECTIVE: To adapt a validated instrument that quantitatively measures stigma among English/Swahili speaking TB (tuberculosis) patients in Kenya, a high burden TB country. METHODS: Following ethical approval, we ... -
Disclosure, consent, opportunity costs, and inaccurate risk assessment deter pediatric HIV testing: a mixed-methods study.
Wagner, AD; O'malley, G; Firdawsi, O; Mugo, C; Njuguna, IN; Maleche-Obimbo, E; Inwani, IW; Wamalwa, DC; John-Stewart, GC; Slyker, JA (University of Nairobi, 2017)(250/250 words) BACKGROUND:: Prompt child HIV testing and treatment is critical; however, children are often not diagnosed until symptomatic. Understanding factors that influence pediatric HIV testing can inform strategies ... -
Risk factors for hypoxia and tachypnea among adolescents with vertically-acquired HIV in Nairobi.
Attia, EF; Weiss, NS; Maleche, Obimbo E; McGrath, CJ; Cagle, A; West, TE; El Antouny, NG; Attwa, M; Crothers, K; Chung, MH. (University of Nairobi, 2017)BACKGROUND: Chronic lung diseases are increasingly recognized complications of vertically-acquired HIV among adolescents in sub-Saharan Africa and may manifest with hypoxia or tachypnea. We sought to determine the ... -
Stakeholder perspectives for optimization of tuberculosis contact investigation in a high-burden setting.
Marangu, D; Mwaniki, H; Nduku, S; Maleche-Obimbo, E; Jaoko, W; Babigumira, J; John-Stewart, G; Rao, D (University of Nairobi, 2017)INTRODUCTION: Optimal tuberculosis contact investigation impacts TB prevention, timely case finding and linkage to care, however data on routine implementation in high burden contexts is limited. MATERIALS AND METHODS: In ... -
Stool Xpert MTB/RIF and urine lipoarabinomannan for the diagnosis of tuberculosis in hospitalized HIV-infected children.
LaCourse, SM; Pavlinac, PB; Cranmer, LM; Njuguna, IN; Mugo, C; Gatimu, J; Stern, J; Walson, JL; Maleche-Obimbo, E; Oyugi, J; Wamalwa, D; John-Stewart, G (University of Nairobi, 2018)BACKGROUND: Tuberculosis (TB) causes substantial morbidity and mortality in HIV-infected children. Sample collection and the paucibacillary nature of TB in children makes diagnosis challenging. Rapid diagnostic tools ... -
Toll-Like Receptor (TLR) 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.
Beima-Sofie, K; Wamalwa, D; Maleche-Obimbo, E; Lingappa, JR; Mackelprang, R; Gantt, S; John-Stewart, G; Casper, C; Slyker, JA. (University of Nairobi, 2017)Polymorphisms in the Toll-Like Receptor (TLR9) 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed ... -
Urgent versus post-stabilisation antiretroviral treatment in hospitalised HIV-infected children in Kenya (PUSH): a randomised controlled trial.
Njuguna, IN; Cranmer, LM; Otieno, VO; Okinyi, HM; Benki-Nugent, S; Richardson, B; Stern, J; Maleche-Obimbo, E; Wamalwa, DC; John-Stewart, GC (University of Nairobi, 2017)BACKGROUND: Urgent antiretroviral therapy (ART) among hospitalised HIV-infected children might accelerate recovery or worsen outcomes associated with immune reconstitution. We aimed to compare urgent versus post-stabilisation ...