Browsing Journal Articles by Title

Safety and Immunogenicity of a Candidate HIV-1 Vaccine,MVA.HIVA, Administered to Healthy Gambian Infants Born to HIV-1/2-Uninfected Mothers

Jaoko, W (University of Nairobi, 2011-09)

Background: The development of a safe and effective HIV-1 vaccine remains a global priority especially in prevention of mother to child transmission of HIV-1 during breastfeeding. Our vaccine platform consists of ...

Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa

Jaoko Walter G.; Nakwagala, Frederick N.; Anzala, Omu; Manyonyi, Gloria Omosa; Birungi, Josephine; Nanvubya, Annet; Bashir, Farah; Bhatta, Kirana; Ogutu, Hilda; Wakasiaka, Sabina; Matu, Lucy; Waruingi, Wambui; Odada, Jane; Oyaro, Micah; Indangasi, Jackton; Ndinya-Achola, JO; Konde, Carol; Mugisha, Emmanuel; Fast, Patricia; Schmidt, Claudia; Gilmour, Jill; Tarragona, Tony; Smith, Carol; Barin, Burc; Dally, Len; Johnson, Bruce; Muluubya, Andrew; Nielsen, Leslie; Hayes, Peter; Boaz, Mark; Hughes, Peter; Hanke, Tom´aˇs; McMichael, Andrew; Bwayo, JJ; Kaleebu, Pontiano (2008)

Summary: The safety and immunogenicity of plasmid pTHr DNA, modified vaccinia virus Ankara (MVA) human immunodeficiency virus type 1 (HIV-1) vaccine candidates were evaluated in four Phase I clinical trials in Kenya and ...

Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, Gabon.

Mordmüller, B; Szywon, K; Greutelaers, B; Esen, M; Mewono, L; Treut, C; Mürbeth, RE; Chilengi, R; Noor, R; Kilama, WL; Imoukhuede, EB; Imbault, N; Leroy, O; Theisen, M; Jepsen, S; Milligan, P; Fendel, R; Kremsner, PG; Issifou, S. (University of Nairobi,College of Health Sciences,, 2010)

Malaria is still one of the major public health threats in sub-Saharan Africa. An effective vaccine could be a sustainable control measure that can be integrated into existing health infrastructures. The malaria vaccine ...

Safety and immunogenicity of the malaria vaccine candidate MSP3 long synthetic peptide in 12-24 months-old Burkinabe children.

Sirima, SB; Tiono, AB; Ouédraogo, A,; Diarra, A; Ouédraogo, AL; Yaro, JB; Ouédraogo, E,; Gansané, A; Bougouma, EC; Kaboré, Y,; Chilengi, R; Soulama, I; Luty, AJ; Druilhe, P; Cousens, S; Nébié, I; Traoré, A (College of Health Sciences,, 2009-10)

BACKGROUND: A Phase Ia trial in European volunteers of the candidate vaccine merozoite surface protein 3 (MSP3), a Plasmodium falciparum blood stage membrane, showed that it induces biologically active antibodies able to ...

Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa

Anzala, Aggrey O.; Jaoko Walter G.; Karita, E.; Kayitenkore, K.; Than, S.; Adams, EM.; Graham, BS.; Koup, RA.; Bailer, RT.; Smith, C.; Dally, L.; Farah, B.; Muvunyi, CM.; Bizimana, J.; Tarragona-Fiol, T.; Bergin, PJ.; Hayes, P.; Ho, M.; Loughran, K.; Komaroff, W.; Stevens, G.; Thomson, H.; Boaz, MJ.; Cox, JH.; Schmidt, C.; Gilmour, J.; Nabel, GJ.; Fast, P. (University of nairobiCollege of health science, 2010)

Abstract BACKGROUND: We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env ...

Safety considerations in process plant design: Legal requirements. “Engineering for Life”

Okoth, MW (University of Nairobi.Department of Food Science, Nutrition & technology, 2003)

Safety design for small biped walking home entertainment robot SDR-4XII

Iribe, M; Moridaira, T; Fukushima, T; Kuroki, Y (University of NairobiSchool of Business studies, 2007)

Safety in a Phase 1 Randomized, Double-Blinded, Placebo-Controlled Trial Evaluating Two Adenovirus HIV Vaccines in Three Different Geographic

Karita, E; Mutua, G; Bekker, L; Gray, G; Page-Shipp, L; Baden, L; Bayingana, R (2013)

Safety issues in voluntary female surgical contraception: peri-operative complications.

Ruminjo, JK; Ngugi, F (Department of Obstetrics and Gynaecology, College of Health Sciences, University of Nairobi, 1993)

PIP: Worldwide, voluntary surgical contraception (VSC) is among the most widely employed of family planning methods. Relatively few vasectomies have been reported in Kenya over the last decade, with VSC in the country ...

Safety nets or poverty traps? The contribution of forests to household welfare in Kenya. Paper presented at the Global Development Network, Ninth Annual Global Development Conference "Security for Development: Confronting Threats

Kabubo-mariara, J (University of Nairobi,School of economics,, 2008)

Safety of a nonoxynol-9 vaginal gel in Kenyan prostitutes. A randomized clinical trial

Martin, HL Jr.; Stevens, CE; Richardson, BA; Rugamba, D; Nyange, PM; Mandaliya, K; Ndinya-Achola, JO; Kreiss, JK (University of NairobiFaculty of medicineFaculty of medicine, 1997-05)

OBJECTIVE: To evaluate the safety and toxicity of once-daily administration of Advantage-24 (Columbia Research Laboratories, Inc., Rockville Centre, NY), a vaginal gel containing 52.5 mg of nonoxynol-9 (N-9), including ...

Safety of the loop electrosurgical excision procedure performed by clinical officers in an HIV primary care setting.

Huchko, MJ; Maloba, M; Bukusi, EA (Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, 2010)

The increasing availability of HIV clinics providing highly active antiretroviral therapy (HAART) has dramatically reduced AIDS-related morbidity and mortality in resource-limited settings. However, the impact of HAART on ...

Safety Of Thyroidectomy At A Rural District Hospital In Kenya.

Ojuka, D K (Department of Surgery, 2007)

The clinical outcome of thyroidectomy may be influenced by among other things, the experience of the surgeon performing the procedure. Furthermore, auditing of any surgical procedure helps in monitoring the safety of the ...

Safety, acceptability, and tolerability of 3 topical microbicides among heterosexual Kenyan men.

Bukusi, EA; Steele, M; Cohen, CR; Nguti, R; Maingi, CW; Thomas, KK; Holmes, KK (2007-04)

To compare the acceptability, tolerability, and safety of 3 topical microbicide formulations (62% ethyl alcohol in emollient gel and 0.1% and 0.4% benzalkonium chloride on a sanitary wipe) for use on male genitalia. This ...

Safety, immunogenicity, and cross-species protection of a plasmid DNA encoding Plasmodium falciparum SERA5 polypeptide, microbial epitopes and chemokine genes in mice and olive baboons.

Onkoba, N; Mumo, RM; Ochanda, H; Omwandho, C; Ozwara, HS; Egwang, TG (University of Nairobi, 2017)

Incorporation of biomolecular epitopes to malarial antigens should be explored in the development of strain-transcending malarial vaccines. The present study sought to determine safety, immunogenicity and cross-species ...