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Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya: a prospective cohort
(2010-05-18)
Abstract
Background
Among children, early mortality following highly active antiretroviral therapy (HAART) remains high. It ...
Breast milk cellular HIV-specific interferon γ responses are associated with protection from peripartum HIV transmission.
(2012)
Breast milk is a major route of infant HIV infection, yet the majority of breast-fed, HIV-exposed infants escape infection by unknown mechanisms. This study aimed to investigate the role of HIV-specific breast milk cells ...
The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life
(2012)
Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease ...
Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.
(University of Nairobi., 2012-10)
Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable ...
Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition
(University of Nairobi., 2010-06)
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women ...
Prevalence, perceptions, and correlates of pediatric HIV disclosure in an HIV treatment program in Kenya.
(2012)
Disclosure to HIV-infected children regarding their diagnosis is important as expanding numbers of HIV-infected children attain adolescence and may become sexually active. In order to define correlates of pediatric disclosure ...
Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission
(University of Nairobi., 2010-01)
HIV-1 transmission in utero accounts for 20-30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with ...
Breast Milk HIV-1 RNA Levels and Female Sex Are Associated With HIV-1–Specific CD8+ T-Cell Responses in HIV-1–Exposed, Uninfected Infants in Kenya
(2011)
Background. Although evidence supports a relationship between human immunodeficiency virus (HIV)–1 exposure and HIV-1−specific CD8+ T cell responses, studies have not demonstrated a direct association between the quantity ...
Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya:
(2010)
Background: Among children, early mortality following highly active antiretroviral therapy (HAART) remains high. It is
important to define correlates of mortality in order to improve outcome.
Methods: HIV-1-infected ...
Utility of Total lymphocyte Count as a Surrogate Marker for CD4 counts in HIV-1 infected Children in Kenya
(2011-09-30)
Abstract
Background
In resource-limited settings, such as Kenya, access to CD4 testing is limited. Therefore, evaluation of less expensive laboratory diagnostics is urgently needed to diagnose immuno-suppression in ...