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Subtype-specific differences in gag-protease-driven replication capacity are consistent with inter-subtype differences in hiv-1 disease progression.
(University of Nairobi, 2017)
There are marked differences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progression have been reported. However, the biological reasons underlying these differences are unknown. ...
Quality of sleep and risk for obstructive sleep apnoea in ambulant individuals with type 2 diabetes mellitus at a tertiary Referral Hospital in Kenya: a cross-sectional, comparative study.
(University of Nairobi, 2017)
BACKGROUND:
Sleep disorders are common and associated with multiple metabolic and psychological derangements. Obstructive sleep apnoea (OSA) is among the most common sleep disorders and an inter-relationship between ...
The tropical lapse rate steepened during the last glacial maximum.
(Unuversity of Nairobi, 2017)
The gradient of air temperature with elevation (the temperature lapse rate) in the tropics is predicted to become less steep during the coming century as surface temperature rises, enhancing the threat of warming in ...
Pregnancy and HIV Disease progression in an early infection cohort from five African countries.
(Unuversity of Nairobi, 2017)
BACKGROUND:
Understanding associations between pregnancy and HIV disease progression is critical to provide appropriate counseling and care to HIV-positive women.
METHODS:
From 2006 to 2011, women less than age 40 ...
Antimalarial pyrido[1,2-a]benzimidazoles: lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and in vivo oral efficacy in a mouse model.
(University of Nairobi, 2017)
Further structure-activity relationship (SAR) studies on the recently identified pyrido[1,2-a]benzimidazole (PBI) antimalarials have led to the identification of potent, metabolically stable compounds with improved in vivo ...
Influence of cattle on browsing and grazing wildlife varies with rainfall and presence of megaherbivores.
(University of Nairobi, 2017)
In many savanna ecosystems worldwide, livestock share the landscape and its resources with wildlife. The nature of interactions between livestock and wildlife is a subject of considerable interest and speculation, yet ...
Preoperative prediction of the size of pure ductal carcinoma in situ using three imaging modalities as compared to histopathological size: does magnetic resonance imaging add value?
(University of Nairobi, 2017)
PURPOSE:
The purpose of this study was to evaluate whether magnetic resonance imaging (MRI) and ultrasonography add value to traditional mammography in an Asian population with ductal carcinoma in situ (DCIS).
METHODS:
Data ...
Head and neck surgical subspecialty training in Africa: Sustainable models to improve cancer care in developing countries.
(University of Nairobi, 2017)
BACKGROUND:
Cancer poses a health crisis in the developing world where surgery is the mainstay of treatment for head and neck cancers. However, a shortage of surgeons with appropriate skills exists. How do we train head ...
Preoperative fasting among adult patients for elective surgery in a Kenyan referral hospital.
(University of Nairobi, 2017)
Background. Preoperative fasting (POF) is physiologically and precautionary important during anesthesia and surgery. POF from midnight has been practiced despite the recommended shorter practice. Objective. Assessing ...
Brief Report: Sexual Violence Against HIV-Positive Women in the Nyanza Region of Kenya: Is Condom Negotiation an Instigator?
(University of Nairobi, 2017)
For people living with HIV, exposure to sexual violence (SV) is associated with decreased adherence to antiretroviral medication, a primary predictor of their survival. Identification of risk factors for SV is a pressing ...