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Now showing items 11-20 of 24
Lack of efficacy of isoniazid chemoprophylaxis in the preventions of tuberculosis in hiv - 1 infected adults
(2008)
Background: Six months of daily isoniazid has been shown to be effective in preventing tuberculosis in the pre-HIV era. Because of underlying immune dysfunction and increased susceptibility to new infection this efficacy ...
A randomized, placebo-controlled trial of monthly azithromycin prophylaxis to prevent sexually transmitted infections and HIV-1 in Kenyan sex workers: study design and baseline findings
(2000)
Our objectives were to describe the baseline findings of a trial of antibiotic prophylaxis to prevent sexually transmitted infections (STIs) and HIV-1 in a cohort of Nairobi female sex workers (FSWs). A questionnaire was ...
Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya
(1996)
BACKGROUND:
There is indirect evidence that HIV-1 exposure does not inevitably lead to persistent infection. Heterogeneity in susceptibility to infection could be due to protective immunity. The objective of this study ...
HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers
(1999)
Objectives: Most HIV-1 transmission is sexual; therefore, immune responses in the
genital mucosa may be important in mediating protection against HIV infection. This
study examined HIV-1-specific mucosal IgA in a cohort ...
Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts
(2000)
In Kenya, the median incubation time to AIDS in seroconverting sex workers is 4 years;
this incubation time is specific to female sex workers.We studied the influence of acute sexually transmitted infections (STIs) on ...
Associations of sexual risk taking among Kenyan female sex workers after enrollment in an HIV-1 prevention trial.
(2005-03)
BACKGROUND:
Female sex workers (FSWs) often lack the ability to negotiate safer sex and are at high risk for HIV-1 infection and sexually transmitted infections (STIs).
METHODS:
Seronegative FSWs were enrolled in an ...
Coinfection with herpes simplex virus type 2 is associated with reduced HIV-specific T cell responses and systemic immune activation.
(University of Nairobi,, 2008)
BACKGROUND:
Chronic coinfection with herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus (HIV) has been associated with an increased HIV viral load and more rapid disease progression, perhaps related to ...
Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi.
(University of Nairobi, 1998-11)
Many people who remain persistently seronegative despite frequent HIV exposure have HIV-specific immune responses. The study of these may provide information about mechanisms of natural protective immunity to HIV-1. We ...
Trends in HIV -1 Incidence in a Cohort of Prostitutes in Kenya: Implications for HIV -1 Vaccine Efficacy Trials
(2000)
Background: Accurate predictions of HIV-I incidence in potential study populations are essential for designing HIV-I vaccine efficacy trials. Lillie information is available on the estimated incidence of HIV-I in such ...
Sexually transmitted infections and vaginal douching in a population of female sex workers in Nairobi, Kenya
(2001)
Objectives:
To assess the association between vaginal douching and sexually transmitted infections (STI) among a group of female sex workers (FSWs) in Nairobi, Kenya.
Methods:
This study was part of a randomised, ...