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Now showing items 61-70 of 101
The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life
(2012)
Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease ...
Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants.
(University of Nairobi., 2012-10)
Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable ...
Morbidity among HIV-1–infected mothers in Kenya prevalence and correlates of illness during 2-year postpartum follow-up
(2007)
Background: Much of the burden of morbidity affecting women of
childbearing age in sub-Saharan Africa occurs in the context of HIV-1
infection. Understanding patterns of illness and determinants of
disease in HIV-1–infected ...
Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition
(University of Nairobi., 2010-06)
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women ...
Low risk of death, but substantial program attrition, in pediatric HIV treatment cohorts in Sub-Saharan Africa
(University of Nairobi., 2008-12)
BACKGROUND:
To date, an estimated 10% of children eligible for antiretroviral treatment (ART) receive it, and the frequency of retention in programs is unknown. We evaluated the 2-year risks of death and loss to follow-up ...
Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children.
(University of Nairobi, 2007)
To describe the early response to World Health Organization (WHO)-recommended nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line highly active antiretroviral therapy (HAART) in HIV-1-infected Kenyan ...
Shadow on the continent: public health and HIV/AIDS in Africa in the 21st century.
(University of Nairobi., 2002-07)
Approaches to the prevention and control of the HIV/AIDS epidemic in Africa have been heavily based on early experiences and policies from industrialised countries, where the disease affects specific risk groups. HIV/AIDS ...
Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1.
(University of Nairobi., 2008-04)
BACKGROUND:
Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune ...
Predictors of mortality in HIV-1 exposed uninfected post-neonatal infants at the Kenyatta National Hospital, Nairobi.
(University of Nairobi., 2005-09)
OBJECTIVES:
To identify potential predictors of mortality, to determine mortality rate and to identify prevalent causes of death in a cohort of HIV-1 exposed uninfected infants.
DESIGN:
Prospective cohort study.
SETT ...
Timing of breast milk HIV-1 transmission: a meta-analysis
(2001-02)
:
To define the frequency and timing of breast milk transmission of HIV-1.
DESIGN:
Meta-analysis of data abstracted from published literature.
SUBJECTS:
Participants in prospective cohort studies of MTCT ...