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A prospective study of vaginal trichomoniasis and HIV-1 shedding in women on antiretroviral therapy
(2011-11-03)
Background
Trichomonas vaginalis has been associated with increased vaginal HIV-1 RNA shedding in antiretroviral therapy (ART)-naïve women. The effect of trichomoniasis on vaginal HIV-1 shedding in ART-treated ...
Albendazole treatment of HIV-1 and helminth co-infection: A randomized, double blind, placebo-controlled trial
(2008)
Several co-infections have been shown to impact the progression of HIV-1 infection. We sought to determine if treatment of helminth co-infection in HIV-1 infected adults impacted markers of HIV-1 disease progression.
...
Infection with Multiple Human Immunodeficiency Virus Type 1 Variants Is Associated with Faster Disease Progression
(University of Nairobi, 2003-12)
Human immunodeficiency virus type 1 (HIV-1)-infected individuals develop a genetically diverse virus population over time, but often only a limited number of viral variants are transmitted from a chronic carrier to a newly ...
The effect of rapid HIV-1 testing on uptake of perinatal HIV-1 interventions: a randomized clinical trial
(2003)
Objective
We examined whether HIV-1 testing using a rapid assay increases the proportion of pregnant women obtaining HIV-1 results and the uptake of perinatal HIV-1 interventions.
Methods
Pregnant women attending ...
Male Perspectives on Incorporating Men into Antenatal HIV Counseling and Testing
(2009)
Male partner involvement in antenatal voluntary HIV counseling and testing (VCT) has been shown to increase uptake of interventions to reduce the risk of HIV transmission in resource-limited settings. We aimed to identify ...
CCR5, RANTES, and SDF-1 polymorphisms and mother-to-child HIV-1 transmission
(2010)
Among 288 HIV-1-infected, breastfeeding women who received zidovudine prophylaxis and were followed with their infants in Nairobi, we found no associations between maternal genetic polymorphisms in CCR5 (59029G/A, 59353T/C, ...
Breast Milk HIV-1 RNA Levels and Female Sex Are Associated With HIV-1–Specific CD8+ T-Cell Responses in HIV-1–Exposed, Uninfected Infants in Kenya
(2011)
Background. Although evidence supports a relationship between human immunodeficiency virus (HIV)–1 exposure and HIV-1−specific CD8+ T cell responses, studies have not demonstrated a direct association between the quantity ...
Changes in the contribution of genital tract infections to HIV acquisition among Kenyan high-risk women from 1993 to 2012
(University of Nairobi, 2015)
Objective: The objective of this study was to understand temporal trends in the contribution of different genital tract infections to HIV incidence over 20 years of follow-up in a cohort of high-risk women.
Design: A ...
Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya:
(2010)
Background: Among children, early mortality following highly active antiretroviral therapy (HAART) remains high. It is
important to define correlates of mortality in order to improve outcome.
Methods: HIV-1-infected ...
Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal HIV-1 shedding
(2007)
Antiretroviral therapy (ART) may decrease HIV-1 infectivity in women by reducing genital HIV-1 shedding. To evaluate the time course and magnitude of decay in cervical and vaginal HIV-1 shedding as women initiate ART. This ...