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Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations
(2004)
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women ...
Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.
(University of Nairobi, 2015)
OBJECTIVE:
Cationic proteins found in cervicovaginal secretions (CVS) are known to contribute to the early antiviral immune response against HIV-infection in vitro. We here aimed to define additional antiviral factors ...
HIV-1 neutralizing activity is correlated with increased levels of chemokines in saliva of HIV-1-exposed uninfected individuals.
(University of Nairobi,, 2008)
AIM:
Mucosal HIV-1 exposure stimulates a variety of mucosal immune responses, including IgA1-mediated virus neutralization, even in the absence of an established infection. We hypothesized that other immune molecules might ...
Acute-Phase Response Proteins Are Overexpressed in Vaginal Mucosa and Plasma of HIV-Resistant Women upon Viral Challenge
(University of Nairobi, 2013)
Background: The primary receptive portals of entry for HIV are
through mucosal surfaces. Our previous studies show that HIVexposed
uninfected individuals (HESN) have unique innate responses
associated with resistance ...
Recombination following superinfection by HIV-1.
(University of nairobi, 2004)
Background: There is increasing recognition of recombinant HIV-1 strains globally, but it has been unclear whether recombination results from superinfection during untreated, chronic infection.
Objective: To search for ...
Too young to take over: - the hidden face of HIV/AIDS : orphans and vulnerable children from a Kenyan perspective
(University of Nairobi, 2004)
Reduced rates of HIV acquisition during unprotected sex by Kenyan female sex wo kers predating population declines in H IV prevalence
(2008)
OBJECTIVES:
Female sex workers (FSWs) form a core group at high risk of both sexual HIV acquisition and secondary transmission. The magnitude of these risks may vary by sexual risk taking, partner HIV prevalence, host ...
Characterization of an HLA-C-restricted CTL response in chronic HIV infection
(University of Nairobi,, 2010-04)
HIV-specific CTL play an important role in the host control of HIV infection. HIV-nef may facilitate escape of HIV-infected cells from CTL recognition by selectively downregulating the expression of HLA-A and HLA-B molecules, ...
Plasma and mucosal fluid from HIV type 1-infected patients but not from HIV type 1-exposed uninfected subjects prevent HIV type 1-exposed DC from infecting other target cells.
(University of Nairobi, 2007-01-23)
Highly exposed persistently seronegative (HEPS) individuals have previously been shown to mount HIV-1-specific humoral and cellular immune responses in the mucosa, despite their uninfected status. It is thus possible that ...