Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations
Date
2004Author
Fang, G
Kuiken, C
Weiser, B
Rowland-Jones, S
Plummer, F
Chen, CH
Kaul, R
Anzala Aggrey O.
Bwayo, JJ
Kimani, J
Philpott, SM
Kitchen, C
Sinsheimer, JS
Gaschen, B
Lang, D
Shi, B
Kemal, KS
Rostron, T
Brunner, C
Beddows, S
Sattenau, Q
Paxinos, E
Oyugi, J
Burger, H
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression
URI
http://www.ncbi.nlm.nih.gov/pubmed/15272396http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17162
Citation
J Infect Dis.2004 Aug 15;190(4):697-701. Epub 2004 Jul 13Publisher
Wadsworth Center, NY State Department of Health, Albany, New York 12208, USA Department of Medical Microbiology, University of NairobiNairobi, Kenya ViroLogicSan Francisco, California
Collections
- Faculty of Health Sciences (FHS) [10387]