dc.contributor.author | Fang, G | |
dc.contributor.author | Kuiken, C | |
dc.contributor.author | Weiser, B | |
dc.contributor.author | Rowland-Jones, S | |
dc.contributor.author | Plummer, F | |
dc.contributor.author | Chen, CH | |
dc.contributor.author | Kaul, R | |
dc.contributor.author | Anzala Aggrey O. | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Kimani, J | |
dc.contributor.author | Philpott, SM | |
dc.contributor.author | Kitchen, C | |
dc.contributor.author | Sinsheimer, JS | |
dc.contributor.author | Gaschen, B | |
dc.contributor.author | Lang, D | |
dc.contributor.author | Shi, B | |
dc.contributor.author | Kemal, KS | |
dc.contributor.author | Rostron, T | |
dc.contributor.author | Brunner, C | |
dc.contributor.author | Beddows, S | |
dc.contributor.author | Sattenau, Q | |
dc.contributor.author | Paxinos, E | |
dc.contributor.author | Oyugi, J | |
dc.contributor.author | Burger, H | |
dc.date.accessioned | 2013-04-26T12:48:37Z | |
dc.date.available | 2013-04-26T12:48:37Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | J Infect Dis.2004 Aug 15;190(4):697-701. Epub 2004 Jul 13 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/15272396 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17162 | |
dc.description.abstract | To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression | en |
dc.language.iso | en | en |
dc.title | Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations | en |
dc.type | Article | en |
local.publisher | Wadsworth Center, NY State Department of Health, Albany, New York 12208, USA | en |
local.publisher | Department of Medical Microbiology, University of NairobiNairobi, Kenya | en |
local.publisher | ViroLogicSan Francisco, California | en |