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Genital inflammation predicts HIV-1 shedding independent of plasma viral load and systemic inflammation
(2012)
In women, genital HIV-1 RNA levels predict the risk of
HIV-1 transmission independent of plasma viral load. To better
understand the factors that contribute to genital HIV-1 shedding, we
evaluated the relationships ...
The post-trial effect of oral periodic presumptive treatment for vaginal infections on the incidence of bacterial vaginosis and Lactobacillus colonization
(2012)
Background
We previously demonstrated a decrease in bacterial vaginosis (BV) and an increase in Lactobacillus colonization among randomized controlled trial (RCT) participants who received monthly oral periodic presumptive ...
A prospective study of vaginal trichomoniasis and HIV-1 shedding in women on antiretroviral therapy
(2011-11-03)
Background
Trichomonas vaginalis has been associated with increased vaginal HIV-1 RNA shedding in antiretroviral therapy (ART)-naïve women. The effect of trichomoniasis on vaginal HIV-1 shedding in ART-treated ...
Infection with Multiple Human Immunodeficiency Virus Type 1 Variants Is Associated with Faster Disease Progression
(University of Nairobi, 2003-12)
Human immunodeficiency virus type 1 (HIV-1)-infected individuals develop a genetically diverse virus population over time, but often only a limited number of viral variants are transmitted from a chronic carrier to a newly ...
Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study
(2007-06-26)
Abstract
Background
Low vitamin E levels are often found in HIV-1 infection, and studies have suggested that higher levels ...
Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
(2002)
Background: Several studies have suggested that sexual transmission of human
herpesvirus 8 (HHV-8) occurs among homosexual men in developed countries. However,
few studies have examined heterosexual HHV-8 transmission, ...
Impact of preconception vaginal microbiota on women's risk of spontaneous preterm birth: protocol for a prospective case-cohort study
(University of Nairobi, 2020)
Introduction: Bacterial vaginosis (BV) and vaginal microbiota disruption during pregnancy are associated with increased risk of spontaneous preterm birth (SPTB), but clinical trials of BV treatment during pregnancy have ...