Genital inflammation predicts HIV-1 shedding independent of plasma viral load and systemic inflammation
Date
2012Author
Blish, Catherine A.
McClelland, R. Scott
Richardson, Barbra A
Jaoko Walter G.
Mandaliya, Kishorchandra
Baeten, Jared M
Overbaugh, Julie
Language
enMetadata
Show full item recordAbstract
In women, genital HIV-1 RNA levels predict the risk of
HIV-1 transmission independent of plasma viral load. To better
understand the factors that contribute to genital HIV-1 shedding, we
evaluated the relationships between genital and plasma cytokine
concentrations and HIV-1 RNA levels. Vaginal, but not plasma,
levels of interferon gamma-induced protein 10 (IP-10) were
significantly associated with vaginal viral load, independent of
plasma viral load. Thus, efforts to decrease HIV-1 transmission
must take into account the role of local inflammation, which is not
necessarily reflected in plasma measurements.
URI
http://www.ncbi.nlm.nih.gov/pubmed/22878424http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9888
Collections
- Faculty of Health Sciences (FHS) [10377]