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Acting Locally: Innate Mucosal Immunity In Resistance To Hiv-1 Infection In Kenyan Commercial Sex Workers.
(University of Nairobi, 2013-06)
Cohort studies of female commercial sex workers (CSWs) in Kenya were among the first to identify highly HIV-1-exposed seronegative (HESN) individuals. As natural resistance is usually mediated by innate immune mechanisms, ...
Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations
(2004)
To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women ...
Immunogenicity Of Sequences Around Hiv-1 Protease Cleavage Sites: Potential Targets And Population Coverage Analysis For A Hiv Vaccine Targeting Protease Cleavage Sites.
(University of Nairobi, 2013-06)
Developing an effective preventative vaccine against HIV-1 has proved to be a great challenge. The classical and proven vaccine approach has failed so far or produced a modest effect, new approaches are needed. In this ...
Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers
(University of Nairobi, 2013-06-26)
Cohort studies of female commercial sex workers (CSWs) in Kenya were among the first to identify highly HIV-1-exposed seronegative (HESN) individuals. As natural resistance is usually mediated by innate immune mechanisms, ...
Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.
(University of Nairobi, 2015)
OBJECTIVE:
Cationic proteins found in cervicovaginal secretions (CVS) are known to contribute to the early antiviral immune response against HIV-infection in vitro. We here aimed to define additional antiviral factors ...
Associations Of Human Leukocyte Antigen-g With Resistance And Susceptibility To Hiv-1 Infection In The Pumwani Sex Worker Cohort.
(University of Nairobi, 2013-01)
OBJECTIVE:
To determine the association between human leukocyte antigens (HLA)-G genotypes and resistance or susceptibility to HIV-1.
DESIGN:
A group of sex workers in Pumwani, Kenya can be epidemiologically defined ...
Polymorphisms In Irf-1 Associated With Resistance To Hiv-1 Infection In Highly Exposed Uninfected Kenyan Sex Workers
(University of Nairobi, 2007-05)
OBJECTIVE:
To determine the correlation between polymorphisms in the IL-4 gene cluster and resistance to HIV-1 infection.
DESIGN:
: A cross-sectional genetic analysis of polymorphisms within the IL-4 gene cluster ...
Altered Dendritic Cell-natural Killer Interaction In Kenyan Sex Workers Resistant To Hiv-1 Infection.
(University of Nairobi, 2012-02)
BACKGROUND:
Natural killer (NK) cells are members of the innate immune system that play an important role in the defense against viral infection. They are also involved in the regulation of adaptive immune responses ...
Decreased Immune Activation In Resistance To Hiv-1 Infection Is Associated With An Elevated Frequency Of Cd4(+)cd25(+)foxp3(+) Regulatory T Cells.
(University of Nairobi, 2009-05)
Human immunodeficiency virus (HIV)-resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural resistance to HIV infection. Emerging data from studies of these ...
The Shaping Of Modern Human Immune Systems By Multiregional Admixture With Archaic Humans
(University of Nairobi, 2011)
Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, ...