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The Breadth and Potency of Passively Acquired Human Immunodeficiency Virus Type 1-Specific Neutralizing Antibodies Do Not Correlate with the Risk of Infant Infection[down-pointing small open triangle]
(2011)
Although a major goal of human immunodeficiency virus type 1 (HIV-1) vaccine efforts is to elicit broad and
potent neutralizing antibodies (NAbs), there are no data that directly demonstrate a role for such NAbs in
protection ...
Effects of Valcyclovir on markers of disease Progression in Postpartum Women Co-Infected with HIV-1 andHerpes Simplex Virus-2
(2012-06)
Objective:
Herpes simplex virus type 2 (HSV-2) suppression has been shown to reduce HIV-1 disease progression in nonpregnant
women and men, but effects on pregnant and postpartum women have not been described.
Methods:
We ...
Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET012 nevirapine versus short-course zidovudine
(2005)
Objective: To compare the effect of perinatal regimens of short-course nevirapine
(HIVNET012)andzidovudine[Thai-CentersforDiseaseControlandPrevention(CDC)
regimen] on breast milk viral shedding and perinatal transmission ...
Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women
(2007)
Objective
To assess the immediate and longer-term effects of the use of hormonal contraception on the progression of HIV-1 disease in postpartum women.
Design
A prospective cohort study.
Methods
Information on ...
Highly Active Antiretroviral Therapy (HAART) versus Zidovudine/Nevirapine Effects on Early Breast Milk HIV-1 RNA: A Phase II Randomized Clinical Trial
(2008)
Background
Defining the effect of antiretroviral regimens on breast milk HIV-1 levels is useful to inform the rational design of strategies to decrease perinatal HIV-1 transmission.
Methods
Pregnant HIV-1 seropositive ...
Evaluation of a single round polymerase chain reaction assay using dried blood spots for diagnosis of HIV-1 infection in infants in an African setting
(2011)
Background
The aim of this study was to develop an economical 'in-house' single round polymerase chain reaction (PCR) assay using filter paper-dried blood spots (FP-DBS) for early infant HIV-1 diagnosis and to evaluate ...
HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women with High Viral Loads
(2012)
There are limited data describing the functional characteristics of HIV-1 specific antibodies in breast milk (BM) and their role in breastfeeding transmission. The ability of BM antibodies to bind HIV-1 envelope, neutralize ...
Association of Levels of HIV-1–Infected Breast Milk Cells and Risk of Mother-to-Child Transmission
(2004)
Understanding how the level of human immunodeficiency virus type 1 (HIV-1)–infected breast milk cells (BMCs) affects HIV transmission via breast-feeding can shed light on the mechanism of infection and aid in establishing ...
CCR5 Promoter Polymorphisms in a Kenyan Perinatal Human Immunodeficiency Virus Type 1 Cohort: Association with Increased 2-Year Maternal Mortality
(2001)
The CCR5 chemokine receptor acts as a coreceptor with CD4 to permit infection by primary macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains. The CCR5Δ32 mutation, which is associated with resistance to ...
Incidence and Correlates of HIV-1 RNA Detection in the Breast Milk of Women Receiving HAART for the Prevention of HIV-1 Transmission
(2012)
Background
The incidence and correlates of breast milk HIV-1 RNA detection were determined in intensively sampled women receiving highly active antiretroviral therapy (HAART) for the prevention of mother-to-child HIV-1 ...