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Now showing items 11-20 of 23
High level of plasma TILRR protein is associated with faster HIV seroconversion
(University of Nairobi, 2022-04)
Background: TILRR (Toll-like Interleukin-1 Receptor Regulator) is a modulator of many genes in NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling. It promotes the production of inflammatory ...
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
(University of Nairobi, 2022-05)
Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used by millions of women worldwide. However, experimental studies have associated DMPA use with genital epithelial barrier disruption and ...
High Level of Pre-Treatment HIV-1 Drug Resistance and Its Association with HLA Class I-Mediated Restriction in the Pumwani Sex Worker Cohort
(University of Nairobi, 2022-01)
Background: We analyzed the prevalence of pre-antiretroviral therapy (ART) drug resistance mutations (DRMs) in a Kenyan population. We also examined whether host HLA class I genes influence the development of pre-ART ...
Socioeconomic Burdens of the COVID-19 Pandemic on LMIC Populations with Increased HIV Vulnerabilities
(University of Nairobi, 2022-02)
Purpose of review: To review the impact of the COVID-19 pandemic and its public health response on key populations at risk of HIV infection, with a focus on sex workers.
Recent findings: Since last year several groups ...
Phylogeographic Assessment Reveals Geographic Sources of Hiv-1 Dissemination Among Men Who Have Sex With Men in Kenya
(University of Nairobi, 2022)
HIV-1 transmission dynamics involving men who have sex with men (MSM) in Africa are not well understood. We investigated the rates of HIV-1 transmission between MSM across three regions in Kenya: Coast, Nairobi, and Nyanza. ...
Geographical Associations of HIV Prevalence in Female Sex Workers From Nairobi, Kenya (2014-2017)
(University of Nairobi, 2023)
Background: Kenya's HIV epidemic is heterogeneously distributed. Although HIV incidence in Kenya has shown signs of recent decline, focused interventions are still needed for female sex workers (FSWs). Geospatially informed ...
Community Insights in Phylogenetic HIV Research: The CIPHR Project Protocol
(University of Nairobi, 2023)
Inferring HIV transmission networks from HIV sequences is gaining popularity in the field of HIV molecular epidemiology. However, HIV sequences are often analyzed at distance from those affected by HIV epidemics, namely ...
High prevalence of vaccine-preventable anal human papillomavirus infections is associated with HIV infection among gay, bisexual, and men who have sex with men in Nairobi, Kenya
(University of Nairobi, 2023)
Background: Human papillomavirus (HPV) infection is associated with anal cancers and is more prevalent in gay, bisexual, and men who have sex with men (gbMSM), partly due to their vulnerability to HIV infection. Baseline ...
Managing motherhood - the experiences of female sex workers in Nairobi, Kenya
(University of Nairobi, 2023)
Women selling sex often face challenges in raising their children in the context of significant socio-economic difficulties and the social stigma inherent in sex work. This paper is based on a cross-sectional qualitative ...
Hydroxychloroquine reduces T cells activation recall antigen responses
(University of Nairobi, 2023)
Background: In the context of the current COVID-19 pandemic, there is still limited information about how people suffering from autoimmune diseases respond to the different COVID vaccines. The fact that they are taking an ...