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Now showing items 11-20 of 39
Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
(University of Nairobi, 2014)
BACKGROUND:
Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the ...
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial.
(2010)
BACKGROUND:
Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited ...
The Expression Analysis of Glucose Transporter 1 Gene in the Pumwani Commercial Sex Worker Cohort, Nairobi, Kenya
(University of Nairobi, 2013)
Background:
Altered susceptibility to HIV1 infection has been
observed in multiple cohort studies. One of the best characterized
HIV1 exposed yet uninfected groups is a commercial sex worker
cohort from Nairobi, Kenya. ...
Characterization of CD8+ T Cell Epitopes Recognizing HIV-1 Epitope Variants
(University Of Nairobi, 2011)
Background: One major challenge in the creation of an HIV-1
vaccine is the extreme genetic diversity of the virus. It is thought
that a more cross-reactive T-cell response would be beneficial in
circumventing this issue. ...
Assessment of the Feasibility of a Different HIV Vaccine Approach
(University Of Nairobi, 2011)
Background: The failure of Merck STEP and Phambili trials and
the modest effect of RV144 trial emphasize the importance of
understanding the correlates of protective immunity. Our study
showed that the epitope recognition ...
Randomized trial of periodic presumptive treatment with high-dose intravaginal metronidazole and miconazole to prevent vaginal infections in HIV-negative women.
(University of Nairobi, 2014)
BACKGROUND:
Vaginal infections are common, frequently recur, and may increase women's risk for sexually transmitted infections (STIs). We tested the efficacy of a novel regimen to prevent recurrent vaginal infections ...
Reducing IRF-1 to levels observed in HESN subjects limits HIV replication, but not the extent of Host immune activation.
(University of Nairobi, 2015-10)
Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40–60% reduction in endogenous IRF-1
(interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early ...
Cohorts for the study of HIV-1—exposed but uninfected individuals: benefits and limitations
(Univerisyt of Nairobi, 2010)
Since the late 1980s, with the first identification of individuals who were exposed to human immunodeficiency virus type 1 (HIV-1) yet remained uninfected, or “HIV-1—resistant” individuals, a large number of cohorts that ...
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
(2011)
The HIV pandemic disproportionately affects women, with most infections acquired through receptive vaginal sex. Although the target cells by which HIV establishes infection in the female genital tract remain poorly defined, ...
Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort.
(University of Nairobi, 2014-07)
We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, ...