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A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy
(University of Nairobi, 2014-05)
Depot medroxyprogesterone acetate (DMPA) use among HIV-1 infected women may increase transmission by increasing plasma and genital HIV-1 RNA shedding. We investigated associations between DMPA use and HIV-1 RNA in plasma ...
HIV-1 Superinfection Occurs Less Frequently Than Initial Infection in a Cohort of High-Risk Kenyan Women.
(2013)
HIV superinfection (reinfection) has been reported in several settings, but no study has been designed and powered to rigorously compare its incidence to that of initial infection. Determining whether HIV infection reduces ...
HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response
(2009)
OBJECTIVE:
To evaluate relationships between HIV-1 evolution, including immune evasion, and markers of disease progression during chronic infection.
DESIGN:
HIV-1 evolution and disease progression markers were evaluated ...
Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women.
(University of Nairobi, 2017)
HIV-1 superinfection, in which an infected individual acquires a second HIV-1 infection from a different partner, is one of the only settings in which HIV acquisition occurs in the context of a pre-existing immune response ...
The Effect Of Treatment Of Vaginal Infections On Shedding Of Human Immunodeficiency Virus Type 1
(University of Nairobi, 2001)
We evaluated the association between the severity of primary human immunodeficiency virus type 1 (HIV-1) illness and HIV-1 plasma virus load before seroconversion using stored plasma samples obtained from 74 prostitutes ...
A prospective study of risk factors for herpes simplex virus type 2 acquisition among high-risk HIV-1 seronegative women in Kenya
(2011)
OBJECTIVES:
Several studies have demonstrated an association between herpes simplex virus type 2 (HSV-2) and HIV-1, but available data on risk factors for HSV-2 acquisition are limited. The objective of this analysis ...
Acute Hiv-1 Infection Illness In Kenyan Women Is Associated With Higher Viral Loads
(University of Nairobi, 2002)
Vitamin A Deficiency And The Acute Phase Response Among Hiv-1-infected And -uninfected Women In Kenya
(University of Nairobi, 2002-06-01)
Among HIV-1-infected individuals, vitamin A deficiency has been associated with faster disease progression and greater infectivity in observational studies, but randomized clinical trials have shown no effect of vitamin A ...
Vitamin A Supplementation And Human Immunodeficiency Virus Type 1 Shedding In Women:
(University of Nairobi, 2002)
{ Observational studies have associated vitamin A deficiency with vaginal shedding of human immunodeficiency virus (HIV) type 1-infected cells and mother-to-child HIV-1 transmission. To assess the effect of vitamin A ...