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Cross-clade CD8(+) T-cell responses with a preference for the predominant circulating clade
(University of Nairobi, 2005-11)
Human immunodeficiency virus (HIV) genetic diversity is a major impediment to the design of a successful vaccine. Even if an HIV vaccine is proven effective, it remains to be seen whether this protection will extend to ...
CD8(+) Lymphocytes Respond To Different Hiv Epitopes In Seronegative And Infected Subjects.
(University of Nairobi, 2001-02)
HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV ...
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial.
(2010)
BACKGROUND:
Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited ...
Human Leucocyte Antigen Supertypes And Immune Susceptibility To Hiv-1, Implications
(University of Nairobi, 2001-11-01)
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
(University of Nairobi,, 2009-09)
BACKGROUND:
The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ...
Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells.
(2015)
BACKGROUND::
The hallmark of HIV infection is progressive but variable rates of systemic and mucosal CD4 depletion, leading to immunodeficiency. The impact of early HIV infection on cervical CD4 T-cell populations in ...
The Expression Analysis of Glucose Transporter 1 Gene in the Pumwani Commercial Sex Worker Cohort, Nairobi, Kenya
(University of Nairobi, 2013)
Background:
Altered susceptibility to HIV1 infection has been
observed in multiple cohort studies. One of the best characterized
HIV1 exposed yet uninfected groups is a commercial sex worker
cohort from Nairobi, Kenya. ...
The role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in Nairobi, Kenya.
(University of Nairobi, 2015)
BACKGROUND:
Little is known about risk factors for persistent high-risk human papillomavirus (hrHPV) infection in low-income settings, and prior research has not quantified the relative duration of hrHPV infections ...
Characterization of CD8+ T Cell Epitopes Recognizing HIV-1 Epitope Variants
(University Of Nairobi, 2011)
Background: One major challenge in the creation of an HIV-1
vaccine is the extreme genetic diversity of the virus. It is thought
that a more cross-reactive T-cell response would be beneficial in
circumventing this issue. ...
Assessment of the Feasibility of a Different HIV Vaccine Approach
(University Of Nairobi, 2011)
Background: The failure of Merck STEP and Phambili trials and
the modest effect of RV144 trial emphasize the importance of
understanding the correlates of protective immunity. Our study
showed that the epitope recognition ...