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Now showing items 21-30 of 37
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
(2012)
BACKGROUND:
Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations.
METHODS:
We conducted a randomized trial ...
Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition
(University of Nairobi., 2010-06)
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women ...
Prevalence, perceptions, and correlates of pediatric HIV disclosure in an HIV treatment program in Kenya.
(2012)
Disclosure to HIV-infected children regarding their diagnosis is important as expanding numbers of HIV-infected children attain adolescence and may become sexually active. In order to define correlates of pediatric disclosure ...
Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters.
(2013)
Plasma HIV-1 RNA set point is an important predictor of HIV-1 disease progression. We hypothesized that inoculum size and HIV-1 exposure prior to HIV-1 transmission may modulate set point. We evaluated predictors of set ...
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.
(2010)
Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital ...
Herpes simplex virus type 2 suppressive therapy with acyclovir or valacyclovir does not select for specific HIV-1 resistance in HIV-1/HSV-2 dually infected persons.
(Univesity of Nairobi, 2011-01)
Recent in vitro studies suggest that acyclovir may directly inhibit HIV-1 replication and can select for a specific HIV-1 reverse transcriptase mutation (V75I) with concomitant loss of an anti-HIV-1 effect. We tested for ...
Immune response to hepatitis B virus vaccination among HIV-1 infected and uninfected adults in Kenya.
(2013)
In studies from high-income countries, human immunodeficiency virus type 1 (HIV-1)-infected persons have diminished responses to hepatitis B virus (HBV) vaccination, compared with HIV-1-uninfected persons, but data from ...
Assisted partner notification services to augment HIV testing and linkage to care in Kenya: study protocol for a cluster randomized trial.
(BMC, 2015)
BACKGROUND:
HIV case-finding and linkage to care are critical for control of HIV transmission. In Kenya, >50% of seropositive individuals are unaware of their status. Assisted partner notification is a public health ...
Seroprevalence of measles IgG among HIV-1-infected and uninfected Kenyan adults.
(University of Nairobi, 2014-02)
Despite global efforts to reduce measles incidence, outbreaks continue to occur in developing countries where HIV-1-infected adults represent a vulnerable population. Immunization campaigns have targeted children, although ...
Incident HSV-2 Infections Are Common Among HIV-1-discordant Couples.
(University of Nairobi, 2013)
Background. The synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) is well known, but lack of knowledge about the epidemiology of HSV-2 acquisition in HIV-1-discordant couples ...