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Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(2012)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ...
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
(2013)
Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ...
An autopsy case of sudden unexplained death caused by malaria.
(University of Nairobi, 2010)
Sudden unexplained deaths, especially those unwitnessed can lead to forensic issues and would necessitate the need for a meticulous and complete postmortem examination including ancillary investigations to discover the ...
Postmortem diagnosis of acute haemorrhagic pancreatitis.
(University of Nairobi, 2010)
Forensic pathologists can help in the investigation of sudden unexpected deaths in co-operation with the officials responsible for the maintenance of law and order to administer justice. Sudden unexpected deaths form the ...
Wilms tumor survival in Kenya.
(University of Nairobi, 2013-06)
PURPOSE:
Survival from Wilms Tumor (WT) exceeds 90% at 5 years in developed nations, whereas at last report, 2-year event-free survival (EFS) in Kenya reached only 35%. To clarify factors linked to these poor outcomes in ...
A stage-wise approach for the analysis of multi-environment trials.
(University of Nairobi, 2012)
Plant breeders and variety testing agencies routinely test candidate genotypes (crop varieties, lines, test hybrids) in multiple environments. Such multi-environment trials can be efficiently analysed by mixed models. A ...
Differential transcription of two highly divergent gut-expressed Bm86 antigen gene homologues in the tick Rhipicephalus appendiculatus
(2011)
The transcriptional control of gene expression is not well documented in the Arthropoda. We describe transcriptional analysis of two exceptionally divergent homologues (Ra86) of the Bm86 gut antigen from Rhipicephalus ...
Comparisons of single-stage and two-stage approaches to genomic selection.
(University of Nairobi, 2013)
Genomic selection (GS) is a method for predicting breeding values of plants or animals using many molecular markers that is commonly implemented in two stages. In plant breeding the first stage usually involves computation ...
The place of knowledge management in influencing lasting health change in Africa: an analysis of AMREF's progress.
(University of Nairobi, 2012)
INTRODUCTION:
AMREF (African Medical and Research Foundation) developed a Knowledge Management Strategy that focused on creating, capturing and applying health knowledge to close the gap between communities and health ...