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dc.contributor.authorOchieng', N
dc.contributor.authorOkechi, H
dc.contributor.authorFerson, S
dc.contributor.authorAlbright, AL
dc.date.accessioned2014-12-03T11:02:18Z
dc.date.available2014-12-03T11:02:18Z
dc.date.issued2014-11
dc.identifier.citationJ Neurosurg Pediatr. 2014 Nov 28:1-6en_US
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/25431903
dc.identifier.urihttp://hdl.handle.net/11295/76080
dc.description.abstractOBJECT Ventriculoperitoneal shunt (VPS) infections are a major cause of morbidity and mortality in patients with hydrocephalus. Most data about these infections come from the Western literature. Few data about infecting organisms in Africa are available, yet knowledge of these organisms is important for the prevention and treatment of infectious complications. The purpose of this study was to determine the organisms cultured from infected shunts in a rural Kenyan hospital. METHODS The authors conducted a retrospective study of patients with VPS infections recorded in the neurosurgical database of BethanyKids at Kijabe Hospital between September 2010 and July 2012. RESULTS Among 53 VPS infections confirmed by culture, 68% occurred in patients who were younger than 6 months. Seventy-nine percent of the infections occurred within 2 months after shunt insertion. Only 51% of infections were caused by Staphylococcus species (Staphylococcus aureus 25%, other Staphylococcus species 26%), whereas 40% were caused by gram-negative bacteria. All S. aureus infections and 79% of other Staphylococcus infections were sensitive to cefazolin, but only 1 of 21 gram-negative bacteria was sensitive to it. The majority of gram-negative bacterial infections were multidrug resistant, but 17 of the 20 gram-negative bacteria were sensitive to meropenem. Gram-negative bacterial infections were associated with worse outcomes. CONCLUSIONS The high proportion of gram-negative infections differs from data in the Western literature, in which Staphylococcus epidermidis is by far the most common organism. Once a patient is diagnosed with a VPS infection in Kenya, immediate treatment is recommended to cover both gram-positive and gram-negative bacterial infections. Data from other Sub-Saharan countries are needed to determine if those countries have the same increased frequency of gram-negative infections.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.subjectEVD = external ventricular drain; ICP = intracranial pressure; VP shunt infections; VPS = ventriculoperitoneal shunt; WBC = white blood cell; antibiotics; bacteria; hydrocephalusen_US
dc.titleBacteria causing ventriculoperitoneal shunt infections in a Kenyan population.en_US
dc.typeArticleen_US
dc.type.materialenen_US


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