Antimicrobial susceptibility patterns of bacteria isolated from sterile sites: cerebral spinal fluid, blood, peritoneal fluid, pleural fluid and synovial fluid at Kenyatta National Hospital
Abstract
Background. Antimicrobial resistance is dramatically increasing worldwide. Much of it due to
inappropriate overuse and is causing significant morbidity and mortality.
Diagnosis of sterile site infections is based on culture of properly collected and processed
samples. Since definitive diagnosis is based on quantitative cultures, the course of antibiotic
therapy should be determined after the culture results have been confirmed. Unfortunately in
most instances empiric treatment is commenced because it is not possible to wait for culture
reports or laboratory facilities are unavailable.
Infections caused by drug resistant organisms are difficult to eradicate because of limited
therapeutic options. With growing antimicrobial resistance in Kenya, reliance on international
guidelines is insufficient and hence a study such as this one is needed to get our local patterns to
help formulate local policies.
Objectives. The general objective of this study was to determine the bacterial isolates identified
from sterile body sites and their antibiotic susceptibility patterns from both inpatients and
outpatients at the Kenyatta National Hospital (KNH) microbiology laboratory, in the period
January to December 2013.
Study design and Methodology. This was a retrospective descriptive study done over three
months using previously available data from the patients’ laboratory files.
After obtaining ethical approval from the KNH/UON- ERC, abstraction of data of samples
collected from sterile sites was done from the existing laboratory database using a coded form,
which was then recorded on a tally sheet .The outcomes that were considered were bacterial
isolates from the respective sterile sites i.e. Cerebral Spinal Fluid (CSF), blood, peritoneal,
pleural and synovial fluid; and their antibiotic susceptibility patterns. Demographic
Subject
cerebral spinal fluidDescription
Thesis Master of Science Degree in Tropical and Infectious Diseases
Collections
Related items
Showing items related by title, author, creator and subject.
-
Evaluation of ascitic fluid polymorphonuclear count & ascitic fluid pH in early diagnosis of spontaneous bacterial peritonitis
Rai, RR; Acharya, KS; Kambam, V; Gandhi, BM; Tandon, BN (Department of Medicine, College of Health Sciences, University of Nairobi, 1988) -
Proteomic Investigation For Gingival Crevicular Fluid Biomarkers In Periodontitis
Hughes, F; Bostanci, N; Clarke, F M; Mulli Tonnie K. (Department of Dental Sciences, 2008)Gingival crevicular fluid (GCF) contains many proteins that could serve as useful diagnostic or prognostic biomarkers of Periodontal Disease. It is possible to detect and analyse the presence of and differential expression ... -
Evaluation of Hydrogeochemical Facies of the Barrier Volcanic Complex Geothermal Fluids in Developing a Conceptual Model
Auko,Leakey O (University of Nairobi, 2013)The Barrier Volcanic Complex (BVC) geothermal prospect is situated on the floor of the northern sector of the Kenya rift, immediately south of Lake Turkana. It is composed of four distinct polygenetic volcanic edifices; ...