dc.contributor.author | Musyoki, Francis | |
dc.date.accessioned | 2014-12-10T14:12:01Z | |
dc.date.available | 2014-12-10T14:12:01Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | http://hdl.handle.net/11295/77197 | |
dc.description.abstract | Background; Epilepsy, anti-epileptic drugs and the reproductive system have complex
interactions.Reproductive endocrine disorders are more common among patients with epilepsy
than in the general population. These disorders have been attributed to both epilepsy and the antiepileptic
drugs. Use of anti-epileptic drugs especially the enzyme inducing drugs increases
hepatic synthesis of Sex Hormone Binding Globulin in both men and women.
The increase in Sex Hormone Binding Globulin level leads to increased binding of testosterone
effectively reducing the fraction of biologically active testosterone available for tissue binding
and action. This may have effects on sexual function and fertility of affected individuals.
Broad objective; Toassess the effects of Anti-Epileptic drugs on male reproductive hormones in
male patients attending neurology clinic at Kenyatta National Hospital.
Study design: Cross sectional comparative survey.
Study population: Sixty three (63) adult male epileptic patients attending neurology clinic at
Kenyatta National Hospital. A comparative group of sixty three (63) healthy adult males
accompanying patients to outpatient clinics.
Study setting: This study was carried out at the neurology clinic.Participants in the comparative
group were recruited from medical, surgical outpatient clinics, Accident and Emergency
department of KNH.
Methods:Patients and age matched comparative cases were consecutively sampled .A venous
blood sample for determination of total testosterone levels and Sex Hormone Binding Globulins
levels was drawn. Free androgen Index was calculated for all study cases and the comparative
group.
Results: The mean testosterone levels was found to be higher in the study group compared to the
comparative group (22.1±8.2 nmol/l versus 15.3±8.2 nmol/, p=<0.001), this difference was
statistically significant. The study group had higher mean levels of Sex Hormone binding
Globulin compared to the comparative group, the difference achieving statistical
significance(62.9±27nmol/l versus 44.6±26.7nmol/l,p=<0.001).The Free Androgen Index was
comparable in the two groups with no statistically significant difference(38.4±14.4 versus
38.9±18.7,p=0.873).
Conclusion: This study showed that men with epilepsy on Anti-epileptic drugs had higher
concentrations of both Total Testosterone and Sex Hormone Binding Globulin than normal
healthy aged matched men. However Free Androgen Index was not reduced in the male patients
compared to the comparative group. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | A comparative study of testosterone,sex hormonebinding globulin and free androgen index levels in men with epilepsy at Kenyatta National Hospital neurology clinic | en_US |
dc.type | Thesis | en_US |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
dc.type.material | en_US | en_US |