Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya.
Date
2015Author
Ingasia, LA
Akala, HM
Imbuga, MO
Opot, BH
Eyase, FL
Johnson, JD
Bulimo, WD
Kamau, E
Language
enMetadata
Show full item recordAbstract
The prevalence of genetic polymorphism(s) at codon 268 in cytochrome b gene which is associated with Atovaquone-proguanil treatment failure was analyzed in 227 Plasmodium falciparum parasites from western Kenya. Prevalence of wild type allele was 63% and Y268S mutant allele was 2%. There were no pure Y268C or Y268N mutant alleles, but mixture with wild type. There was a correlation between parasite IC50 and parasite genetic polymorphism; mutant alleles had higher IC50s than the wild type
Citation
Ingasia LA, Akala HM , Imbuga MO, Opot BH, Eyase FL, Johnson JD, Bulimo WD, Kamau E. Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya. Antimicrob. Agents Chemother.. 2015.Publisher
University of Nairobi