| dc.contributor.author | Ingasia, LA | |
| dc.contributor.author | Akala, HM | |
| dc.contributor.author | Imbuga, MO | |
| dc.contributor.author | Opot, BH | |
| dc.contributor.author | Eyase, FL | |
| dc.contributor.author | Johnson, JD | |
| dc.contributor.author | Bulimo, WD | |
| dc.contributor.author | Kamau, E | |
| dc.date.accessioned | 2015-01-28T07:33:55Z | |
| dc.date.available | 2015-01-28T07:33:55Z | |
| dc.date.issued | 2015 | |
| dc.identifier.citation | Ingasia LA, Akala HM , Imbuga MO, Opot BH, Eyase FL, Johnson JD, Bulimo WD, Kamau E. Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya. Antimicrob. Agents Chemother.. 2015. | en_US |
| dc.identifier.uri | http://hdl.handle.net/11295/80101 | |
| dc.description.abstract | The prevalence of genetic polymorphism(s) at codon 268 in cytochrome b gene which is associated with Atovaquone-proguanil treatment failure was analyzed in 227 Plasmodium falciparum parasites from western Kenya. Prevalence of wild type allele was 63% and Y268S mutant allele was 2%. There were no pure Y268C or Y268N mutant alleles, but mixture with wild type. There was a correlation between parasite IC50 and parasite genetic polymorphism; mutant alleles had higher IC50s than the wild type | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of Nairobi | en_US |
| dc.title | Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya. | en_US |
| dc.type | Article | en_US |
| dc.type.material | en | en_US |
