The antinociceptive effects of hydrazinocurcumin
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Date
2013Author
Okalebo, Faith. A.
Ngaruiya, Mathew N.
Changwony, Paul
Oluka, Margaret O.
Karume, Daniel W.
Language
enMetadata
Show full item recordAbstract
Background Analgesics in clinical used have many side effects and are not always effective. Hence need for safer and
more effective agents. Hydrazinocurcumin is an azole derivative of the natural product curcumin. It is reported to
have antiangiogenic, antiplasmodial and cytotoxic activities.
Objective: The antinociceptive activity of hydrazinocurcumin was evaluated.
Methodology: Hydrazinocurcumin was synthesized by reacting curcumin with hydrazine at room temperature and a
yield of 81 % was obtained. It was investigated for in vivo antinociceptive activity using the acetic acid inducedwrithing
test while central antinociceptive activity was investigated using the hot plate method.
Results: Hydrazinocurcumin (22.4mg/kg) reduced acetic acid induced writhing by 42.7%. Its activity was comparable
to that of sodium salicylate (50mg/kg). It did not increase reaction times of mice on the hot plate after 30 minutes of
administration but increased the reaction time after 60 minutes.
Discussion: The findings suggest that hydrazinocurcmin has peripheral and delayed centrally mediated
antinociceptive activity.
Conclusion: Hydrazinocurcumin may be a potential lead compound for agents with analgesic effects.
Citation
Okalebo FA, Ngaruiya MN, Changwony P, Oluka MN, Karume DW, Maloba KN. "The antinociceptive effects of Hydrazinocurcumin." Afr. J. Pharmacol. Ther.. 2013;2(2):66-69.Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]