Browsing Faculty of Science & Technology (FST) by Author "Patel, JP"

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

Huberman, K; Aminova, O; Thomas, S; Dolgalev, L; Van Vlierberghe, P; Racevskis, J; Sun, Z; Fernandez, H; Figueroa, ME; Gönen, M; Patel, JP; Cheng, J; van den Brink, MR; Litzow, M; Gallagher, RE; Ketterling, RP; Viale, A; Socci, ND; Heguy, A; Cherry, A; Vance, G; Higgins, RR; Levine, RL; Abdel-Wahab, O; Melnick, A; Tallman, MS; Paietta, E; Ferrando, A; Luger, S; Rowe, JM; Lazarus, HM (College of Biological and Physical Sciences ,Department of physics, 2012)

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated ...

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

Levine, RL; Abdel-Wahab, O; Brennan, CW; Godley, LA; Melnick, A; Mason, CE; Gonen, M; Bhatt, PK; Socci, N; Hassimi, M; Heguy, A; Viale, A; Li, J; Mollica, L; Hamilou, Z; Provost, S; Vasanthakumar, A; Busque, L; Patel, JP; Figueroa, ME (College of Biological and Physical Sciences ,Department of physics, 2012)

Abstract Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated ...

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

Meyer, JA; Wang, J; Hogan, LE; Yang, JJ; Dandekar, S; Patel, JP; Tang, Z; Zumbo, P; Li, S; Zavadil, J; Levine, RL; Cardozo, T; Hunger, SP; Raetz, EA; Evans, WE; Morrison, DJ; Mason, CE; Carroll, WL (College of Biological and Physical Sciences ,Department of physics, 2013)

Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ...

The role of mutations in epigenetic regulators in myeloid malignancies

Shih, AH; Abdel-Wahab, O; Patel, JP; Levine, RL (College of Biological and Physical Sciences ,Department of physics, 2012)

The role of mutations in epigenetic regulators in myeloid malignancies. Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative ...

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

DiNardo, CD; Propert, KJ; Loren, AW; Paietta, E; Sun, Z; Levine, RL; Straley, KS; Yen, K; Patel, JP; Agresta, S; Abdel-Wahab, O; Perl, AE; Litzow, MR; Rowe, JM; Lazarus, HM; Fernandez, HF; Margolis, DJ; Tallman, MS; Luger, SM; Carroll, M (College of Biological and Physical Sciences ,Department of physics, 2013)

Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...

Spectral analysis of ground magnetic data in Magadi area, Southern Kenya rift

Githiri, JG; Patel, JP; Barongo, JO; Karanja, PK (Jomo-Kenyatta University of Agriculture, Science and Technology, Department of PhysicsUniversity of Nairobi, Department of PhysicsUniversity of Nairobi, Department of GeologyJomo-Kenyatta University of Agriculture, Science and Technology Department of Physics, 2012)

The area surrounding Lake Magadi in the southern Kenya rift is characterized by hot springs that issue from fractures distributed along the shores of the lake. Presence of earthquake swarms that cluster in northern margin ...