Now showing items 1-1 of 1

    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis 

      Levine, RL; Abdel-Wahab, O; Brennan, CW; Godley, LA; Melnick, A; Mason, CE; Gonen, M; Bhatt, PK; Socci, N; Hassimi, M; Heguy, A; Viale, A; Li, J; Mollica, L; Hamilou, Z; Provost, S; Vasanthakumar, A; Busque, L; Patel, JP; Figueroa, ME (College of Biological and Physical Sciences ,Department of physics, 2012)
      Abstract Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated ...