Browsing Faculty of Science & Technology (FST) by Author "Patel, JP"
Now showing items 1-20 of 30
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Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis
Diab, A; Zickl, L; Abdel-Wahab, O; Jhanwar, S; Gulam, MA; Panageas, KS; Patel, JP; Jurcic, J; Maslak, P; Paietta, E; Mangan, JK; Carroll, M; Fernandez, HF; Teruya-Feldstein, J; Luger, SM; Douer, D; Litzow, MR,; Lazarus, HM; Rowe, JM; Levine, RL; Tallman, MS (College of Biological and Physical Sciences ,Department of physics, 2013)Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, ... -
APPLICATION OF EULER DECONVOLUTION TECHNIQUE IN DETERMINING DEPTHS TO MAGNETIC STRUCTURES IN MAGADI AREA, SOUTHERN KENYA RIFT
Githiri, JG; Patel, JP; Barongo, JO; Karanja, PK (2011)Magadi area is located in the southern part of the Kenyan rift, an active continental rift that is part of the East African Rift system. Thermal manifestations in the form of hot springs in the northern and southern shores ... -
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
Levine, RL; Bernstein, BE; Aifantis, I; Jaffe, JD; Nimer, SD; Melnick, A; Carroll, M; Abdel-Wahab, O; Park, CY; Taylor, JE; Zhao, X; Perna, F; Koche, R; Chung, YR; Patel, JP; Pandey, S; Shih, AH; Hricik, T; Gao, J; LaFave, LM; Adli, M (College of Biological and Physical Sciences ,Department of physics, 2012)Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ... -
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900
Gönen, M; Sun, Z; Figueroa, ME; Patel, JP; Abdel-Wahab, O; Racevskis, J; Ketterling, RP; Fernandez, H; Rowe, JM; Tallman, MS; Melnick, A; Levine, RL; Paietta, E (College of Biological and Physical Sciences ,Department of physics, 2012)We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ... -
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
Brocks, DR; Hamdy, DA; Ben-Eltriki, M; Patel, JP; El-Kadi, AO (College of Biological and Physical Sciences ,Department of physics, 2013)Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ... -
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
Patel, JP; Hamdy, DA; El-Kadi, AO; Brocks, DR (College of Biological and Physical Sciences ,Department of physics, 2012)Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ... -
Evaluation of Geophagia as a Pathway for Internal Exposure to Ionizing Radiation
Mustapha, AO; Patel, JP; Ngigi, EN; Rathore, IVS; Hashim, NO (University of Nairobi, 2015)Geophagia, the deliberate ingestion of soil, is a complex eating habit found among animals and human beings around the world. Among other reasons soil ingestion is perceived as a source of essential mineral supplements, ... -
How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia?
Patel, JP; Levine, RL (College of Biological and Physical Sciences ,Department of physics, 2012)Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and the majority of patients with AML die from relapsed disease. Although many studies over the past 4 decades have identified disease ... -
Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930
Patel, JP; Kuang, YH; Chen, ZS; Korlipara, VL (College of Biological and Physical Sciences ,Department of physics, 2011)The quinoline domain of OSI-930, a dual inhibitor of receptor tyrosine kinases (RTKs) c-Kit and KDR, was modified in an effort to further understand the SAR of OSI-930, and the binding site characteristics of c-Kit and ... -
An investigation of the repeatability of calibration factors in gamma-ray spectrometry of geological materials
Mustapha, AO; Patel, JP; Rathore, IV; Hashim, NO; Otwoma, D (Department of Physics, University of Nairobi, 2004)A NaI(Tl)-based gamma spectrometer for the analysis of geological materials was calibrated using the IAEA reference materials RGU-1, RGTH-1 and RGK-1. To simulate typical geological samples, two additional standards were ... -
Lower Proterozoic Polar Wander Path for Africa
Patel, JP (University of Nairobi,Department of Physics, 1983) -
Magnetic and Paleomagnetic Results of Nippising diabase, Canada
Patel, JP; Palmer, HC (University of Nairobi,Department of Physics, 1971) -
More on normal prothrombin times in the presence of therapeutic levels of rivaroxaban - early experience from King's College Hospital
Patel, JP; Roberts, LN; Chitongo, PB; Patel, RK; Arya, R (College of Biological and Physical Sciences ,Department of physics, 2013) -
New antitrypanosomal tetranotriterpenoids from Azadirachta Indica
Patel, JP; Gacii, P (University of Nairobi, 1972-07)Organic extracts of the leaves of Azadirachta indica A. Juss. yielded ten antitrypanosomal terpenoids. Three of these (1 – 3), are novel and are derivatives of nimbolide and nimbin. They were extracted from chloroform fraction ... -
Optimization Of X-ray Fluorescence Elemental Analysis: An Example From Kenya
Angeyo, KH; Patel, JP; Mangala, JM; Narayana, DGS (University of Nairobi, 1998-07)A systematic study and application of a radioisotope excited energy dispersive X-ray fluorescence analysis method to multi-elemental determination in Kenyan rock samples whose supporting matrices are of light elements is ... -
OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
Kuang, YH; Patel, JP; Sodani, K; Wu, CP; Liao, LQ; Patel, A; Tiwari, AK; Dai, CL; Chen, X; Fu, LW; Ambudkar, SV; Korlipara, VL; Chen, ZS (College of Biological and Physical Sciences ,Department of physics, 2012)OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors. A series of fifteen pyridyl and phenyl analogues of OSI-930 ... -
Paleomagnetic of the Still Water Complex , Beartooth Mountains, Montana, U.S.A.,
Geissman, J; Patel, JP (University of Nairobi,Department of Physics, 1983) -
Paleomagnetic studies in Kenya
Patel, JP (University of Nairobi,Department of Physics, 1967) -
The Paleomagnetism of Granites from Kenya
Patel, JP (University of Nairobi,Department of Physics, 1980) -
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies
Oyer, JA; Huang, X; Zheng, Y; Shim, J; Ezponda, T; Carpenter, Z; Allegretta, M; Okot-Kotber, CI; Patel, JP; Melnick, A; Levine, RL; Mackerell, AD; Kelleher, NL; Licht, JD; Popovic, R (College of Biological and Physical Sciences ,Department of physics, 2013)