Browsing Faculty of Science & Technology (FST) by Author "Tallman, MS"

Now showing items 1-4 of 4

    • Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis 

      Diab, A; Zickl, L; Abdel-Wahab, O; Jhanwar, S; Gulam, MA; Panageas, KS; Patel, JP; Jurcic, J; Maslak, P; Paietta, E; Mangan, JK; Carroll, M; Fernandez, HF; Teruya-Feldstein, J; Luger, SM; Douer, D; Litzow, MR,; Lazarus, HM; Rowe, JM; Levine, RL; Tallman, MS (College of Biological and Physical Sciences ,Department of physics, 2013)
      Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, ...

    • CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900 

      Gönen, M; Sun, Z; Figueroa, ME; Patel, JP; Abdel-Wahab, O; Racevskis, J; Ketterling, RP; Fernandez, H; Rowe, JM; Tallman, MS; Melnick, A; Levine, RL; Paietta, E (College of Biological and Physical Sciences ,Department of physics, 2012)
      We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ...

    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia 

      Huberman, K; Aminova, O; Thomas, S; Dolgalev, L; Van Vlierberghe, P; Racevskis, J; Sun, Z; Fernandez, H; Figueroa, ME; Gönen, M; Patel, JP; Cheng, J; van den Brink, MR; Litzow, M; Gallagher, RE; Ketterling, RP; Viale, A; Socci, ND; Heguy, A; Cherry, A; Vance, G; Higgins, RR; Levine, RL; Abdel-Wahab, O; Melnick, A; Tallman, MS; Paietta, E; Ferrando, A; Luger, S; Rowe, JM; Lazarus, HM (College of Biological and Physical Sciences ,Department of physics, 2012)
      BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated ...

    • Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia 

      DiNardo, CD; Propert, KJ; Loren, AW; Paietta, E; Sun, Z; Levine, RL; Straley, KS; Yen, K; Patel, JP; Agresta, S; Abdel-Wahab, O; Perl, AE; Litzow, MR; Rowe, JM; Lazarus, HM; Fernandez, HF; Margolis, DJ; Tallman, MS; Luger, SM; Carroll, M (College of Biological and Physical Sciences ,Department of physics, 2013)
      Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...