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Anthraquinones of the roots of Pentas micrantha
(University of Nairobi, 2012-12)
Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 ...
Comparison of two microdiffusion methods used to measure ionizable fluoride in cow's milk
(2011)
Two microdiffusion methods for measuring ionizable fluoride in cows' milk have been compared. The comparison includes diffusion time, amount of fluoride in spiked and unspiked milk samples and the effect of aluminium as ...
Study on the microstructure of African wild silk cocoon shells and fibers
(2012-01)
Silk fibers and cocoon shells from four African wild silkmoths Gonometa postica, Anaphe panda, Argema mimosae and Epiphora bauhiniae-were studied to gain insight into the structure-property-function relations and potential ...
The palaeo-lake Suguta and its importance for understanding lake level fluctuations in the East African Rift System
(University of Nairobi, 2010)
We studied the most recent dry-wet-dry cycle in the presently arid Suguta Valley in the Northern Kenya Rift where a 300-m-deep lake has formed during the so-called African Humid Period (AHP, 14.8-5.5 ka BP). Hydromodeling ...
Steady rifting in northern Kenya inferred from deformed Holocene lake shorelines of the Suguta and Turkana basins.
(University of Nairobi, 2012-05-15)
A comparison of deformation rates in active rifts over different temporal scales may help to decipher variations in their structural evolution, controlling mechanisms, and evolution of sedimentary environments through time. ...
Cytotoxic lupane-type triterpenoids from Acacia mellifera.
(2004)
One new and eight previously described lupane-type metabolites were isolated for the first time from Acacia mellifera (Leguminosae). Based on spectral analyses, the structure of the new compound was elucidated as ...
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
(2012)
Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ...
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(2012)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ...
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
(2013)
Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ...