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Now showing items 11-20 of 30

An investigation of the repeatability of calibration factors in gamma-ray spectrometry of geological materials

Mustapha, AO; Patel, JP; Rathore, IV; Hashim, NO; Otwoma, D (2004)

A NaI(Tl)-based gamma spectrometer for the analysis of geological materials was calibrated using the IAEA reference materials RGU-1, RGTH-1 and RGK-1. To simulate typical geological samples, two additional standards were ...

OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance

Kuang, YH; Patel, JP; Sodani, K; Wu, CP; Liao, LQ; Patel, A; Tiwari, AK; Dai, CL; Chen, X; Fu, LW; Ambudkar, SV; Korlipara, VL; Chen, ZS (2012)

OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors. A series of fifteen pyridyl and phenyl analogues of OSI-930 ...

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

Levine, RL; Abdel-Wahab, O; Brennan, CW; Godley, LA; Melnick, A; Mason, CE; Gonen, M; Bhatt, PK; Socci, N; Hassimi, M; Heguy, A; Viale, A; Li, J; Mollica, L; Hamilou, Z; Provost, S; Vasanthakumar, A; Busque, L; Patel, JP; Figueroa, ME (2012)

Abstract Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated ...

Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

Oyer, JA; Huang, X; Zheng, Y; Shim, J; Ezponda, T; Carpenter, Z; Allegretta, M; Okot-Kotber, CI; Patel, JP; Melnick, A; Levine, RL; Mackerell, AD; Kelleher, NL; Licht, JD; Popovic, R (2013)

Optimization Of X-ray Fluorescence Elemental Analysis: An Example From Kenya

Angeyo, KH; Patel, JP; Mangala, JM; Narayana, DGS (University of Nairobi, 1998-07)

A systematic study and application of a radioisotope excited energy dispersive X-ray fluorescence analysis method to multi-elemental determination in Kenyan rock samples whose supporting matrices are of light elements is ...

Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930

Patel, JP; Kuang, YH; Chen, ZS; Korlipara, VL (2011)

The quinoline domain of OSI-930, a dual inhibitor of receptor tyrosine kinases (RTKs) c-Kit and KDR, was modified in an effort to further understand the SAR of OSI-930, and the binding site characteristics of c-Kit and ...

More on normal prothrombin times in the presence of therapeutic levels of rivaroxaban - early experience from King's College Hospital

Patel, JP; Roberts, LN; Chitongo, PB; Patel, RK; Arya, R (2013)

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia

DiNardo, CD; Propert, KJ; Loren, AW; Paietta, E; Sun, Z; Levine, RL; Straley, KS; Yen, K; Patel, JP; Agresta, S; Abdel-Wahab, O; Perl, AE; Litzow, MR; Rowe, JM; Lazarus, HM; Fernandez, HF; Margolis, DJ; Tallman, MS; Luger, SM; Carroll, M (2013)

Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...

CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900

Gönen, M; Sun, Z; Figueroa, ME; Patel, JP; Abdel-Wahab, O; Racevskis, J; Ketterling, RP; Fernandez, H; Rowe, JM; Tallman, MS; Melnick, A; Levine, RL; Paietta, E (2012)

We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ...

The role of mutations in epigenetic regulators in myeloid malignancies

Shih, AH; Abdel-Wahab, O; Patel, JP; Levine, RL (2012)

The role of mutations in epigenetic regulators in myeloid malignancies. Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative ...