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Now showing items 11-18 of 18
Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930
(2011)
The quinoline domain of OSI-930, a dual inhibitor of receptor tyrosine kinases (RTKs) c-Kit and KDR, was modified in an effort to further understand the SAR of OSI-930, and the binding site characteristics of c-Kit and ...
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
(2013)
Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900
(2012)
We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ...
The role of mutations in epigenetic regulators in myeloid malignancies
(2012)
The role of mutations in epigenetic regulators in myeloid malignancies.
Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative ...
APPLICATION OF EULER DECONVOLUTION TECHNIQUE IN DETERMINING DEPTHS TO MAGNETIC STRUCTURES IN MAGADI AREA, SOUTHERN KENYA RIFT
(2011)
Magadi area is located in the southern part of the Kenyan rift, an active continental rift that is part of the East African Rift system. Thermal manifestations in the form of hot springs in the northern and southern shores ...
Evaluation of Geophagia as a Pathway for Internal Exposure to Ionizing Radiation
(University of Nairobi, 2015)
Geophagia, the deliberate ingestion of soil, is a complex eating habit found among animals and human beings around the world. Among other reasons soil ingestion is perceived as a source of essential mineral supplements, ...
Spectral analysis of ground magnetic data in Magadi area, Southern Kenya rift
(2012)
The area surrounding Lake Magadi in the southern Kenya rift is characterized by hot springs that
issue from fractures distributed along the shores of the lake. Presence of earthquake swarms that
cluster in northern margin ...