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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
(2012)
Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ...
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(2012)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ...
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
(2013)
Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ...
A stage-wise approach for the analysis of multi-environment trials.
(University of Nairobi, 2012)
Plant breeders and variety testing agencies routinely test candidate genotypes (crop varieties, lines, test hybrids) in multiple environments. Such multi-environment trials can be efficiently analysed by mixed models. A ...
Differential transcription of two highly divergent gut-expressed Bm86 antigen gene homologues in the tick Rhipicephalus appendiculatus
(2011)
The transcriptional control of gene expression is not well documented in the Arthropoda. We describe transcriptional analysis of two exceptionally divergent homologues (Ra86) of the Bm86 gut antigen from Rhipicephalus ...
Comparisons of single-stage and two-stage approaches to genomic selection.
(University of Nairobi, 2013)
Genomic selection (GS) is a method for predicting breeding values of plants or animals using many molecular markers that is commonly implemented in two stages. In plant breeding the first stage usually involves computation ...
The distribution of large herbivore hotspots in relation to environmental and anthropogenic correlates in the Mara region of Kenya.
(University of Nairobi, 2012)
1. The distributions of large herbivores in protected areas and their surroundings are becoming increasingly restricted by changing land use, with adverse consequences for wildlife populations. 2. We analyse changes in ...
Genomic selection using regularized linear regression models: ridge regression, lasso, elastic net and their extensions.
(University of Nairobi, 2012)
BACKGROUND:
Genomic selection (GS) is emerging as an efficient and cost-effective method for estimating breeding values using molecular markers distributed over the entire genome. In essence, it involves estimating the ...
"Petrified ears" with idiopathic adult-onset pituitary insufficiency.
(University of Nairobi, 2012)
"Petrified ears" or calcification of auricular cartilage is an uncommonly reported condition. The most common causes of this phenomenon are local trauma, frost bite, and inflammation. Adrenal insufficiency is the most ...
Hydrologic Analysis For River Nyando Using SWAT
(University of Nairobi, 2011)
The Nyando River is one of the major Rivers in the Lake Victoria Basin. It drains parts
of Nandi, Kericho and Nyando districts. It has a catchment area of about 3600km−2
of Western Kenya and an average discharge of ...