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Antileukemic compounds derived by chemical modification of macrocyclic trichothecenes. 2. Derivatives of roridins A and H and verrucarins A and J
(1984-02)
Various 8 beta-hydroxy, 16-hydroxy, and 9 beta,10 beta-epoxy derivatives of roridins A and H and verrucarins A and J have been prepared and tested in vivo against P388 mouse leukemia. The 9 beta,10 beta-epoxy derivatives ...
The Mystery of Trichothecene Antibiotics in Baccharis Species
(1988-08)
The Brazilian higher plant Baccharis coridifolia has been shown to synthesize de novo a series of highly toxic macrocyclic trichothecene antibiotics heretofore found to be produced only by fungi. These compounds are produced ...
12,13-Deoxytrichoverrins from Myrothecium verrucaria
(1989-05)
The structures of two new diastereoisomeric 12,13-deoxytrichothecenes have been established by a combination of nmr and mass spectroscopy.
Interaction Between the Antibiotic Trichothecenes and the Higher Plant Baccharis megapotamica
(1981-10)
The Brazilian shrub Baccharis megapotamica contains significant amounts of antibiotic trichothecenes. When these plants are grown in the United States, they are devoid of the mycotoxins. Feeding experiments with fungus-produced ...