Association between cellular immune activation, target cell frequency, and risk of human immunodeficiency virus type 1 superinfection
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Date
2014Author
Blish, Catherine A.
Dogana, Ozge C
Jaoko, Walter
McClelland, R. Scott
Mandaliya, Kishorchandra
Katherine, Odem-Davisa
Barbra, A. Richardsone
Overbaugha, Julie
Language
enMetadata
Show full item recordAbstract
We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation.
Citation
Blish, Catherine A., et al. "Association between cellular immune activation, target cell frequency, and risk of human immunodeficiency virus type 1 superinfection." Journal of virology 88.10 (2014): 5894-5899.Publisher
University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]