Browsing Faculty of Health Sciences (FHS) by Author "c2bb3823-71f5-476c-b9dc-5ef73338503f"
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The role of natural products in drug discovery and development against neglected tropical diseases
Cheuka, Peter M; Mayoka, Godfrey; Mutai, Peggoty; Chibale, Kelly (University of Nairobi, 2017)Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible ... -
Synthesis and biological evaluation of 4 arylcoumarin analogues as tubulin-targeting antitumor agents
Mutai, Peggoty; Breuzard, Gilles; Pagano, Alessandra; Allegro, Diane; Peyrot, Vincent; Chibale, Kelly (University of Nairobi, 2017)The synthesis of twenty-six 4-arylcoumarin analogues of combretastatin A-4 (CA-4) led to the identification of two new compounds (25 and 26) with strong cytotoxic activity. Both compounds had a high cytotoxic effect on a ...